DegronMD

Uniprot ID: Q53SF7

Source protein: Cordon-bleu protein-like 1

Source gene: COBLL1

Class: DEG_APCC_DBOX_1

Location: 293:301

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.991

ASA_SCORE: 106.6

COIL: 0.9536

CONS_SCORE: 0.4099

DSS_SCORE: 0.7305

HELIX: 0.0176

FCONS_SCORE: 1.0001

RIG_SCORE: 0.6129

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R294W	TCGA-06-0122	GBM	TCGA	RRAPLPPMP	DEG_APCC_DBOX_1	0.8634
p.R294W	TCGA-FI-A2D5	UCEC	TCGA	RRAPLPPMP	DEG_APCC_DBOX_1	0.8634
p.R294W	DO12514	GBM	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	0.8634
p.R294W	DO41331	UCEC	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	0.8634
p.A295S	HCC-15	lung	COSMIC	RRAPLPPMP	DEG_APCC_DBOX_1	0.6477
p.P298L	TCGA-AP-A056	UCEC	TCGA	RRAPLPPMP	DEG_APCC_DBOX_1	0.6471
p.P298L	DO43971	UCEC	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	0.6471
p.P299L	TCGA-AP-A0LM	UCEC	TCGA	RRAPLPPMP	DEG_APCC_DBOX_1	0.6471
p.P299L	DO222843	MELA	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	0.6471
p.P299L	DO43306	UCEC	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	0.6471
p.P299S	TCGA-W3-A825	SKCM	TCGA	RRAPLPPMP	DEG_APCC_DBOX_1	0.5641
p.P299S	DO51272	SKCM	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	0.5641
p.P301S	TCGA-ZF-AA4W	BLCA	TCGA	RRAPLPPMP	DEG_APCC_DBOX_1	0.5641
p.P301S	DO219089	BLCA	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	0.5641
p.V306A	DO228536	GACA	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	0.1944
p.P307S	TCGA-W3-AA1R	SKCM	TCGA	RRAPLPPMP	DEG_APCC_DBOX_1	0.1667
p.P307S	DO51275	SKCM	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	0.1667
p.P286T	DO23394	LINC	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	0.1389
p.Q308P	DO219881	SKCA	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	0.1389
p.P286L	ACH-001738	Leukemia	CCLE	RRAPLPPMP	DEG_APCC_DBOX_1	0.1389
p.P286L	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	RRAPLPPMP	DEG_APCC_DBOX_1	0.1389
p.D309G	TCGA-B5-A11E	UCEC	TCGA	RRAPLPPMP	DEG_APCC_DBOX_1	0.1111
p.D309G	DO41644	UCEC	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	0.1111
p.L310F	DO220885	MELA	ICGC	RRAPLPPMP	DEG_APCC_DBOX_1	0.0833
p.A311E	TCGA-DU-6402	LGG	TCGA	RRAPLPPMP	DEG_APCC_DBOX_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53SF7	Cordon-bleu protein-like 1	DEG_APCC_DBOX_1	293:301	RRAPLPPMP	APC,CDC20,FZR1	0.991	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons