DegronMD

Uniprot ID: Q9BT92

Source protein: Trichoplein keratin filament-binding protein

Source gene: TCHP

Class: DEG_APCC_DBOX_1

Location: 83:91

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.627

ASA_SCORE: 105.7333

COIL: 0.0176

CONS_SCORE: 0.6906

DSS_SCORE: 0.4173

HELIX: 0.983

FCONS_SCORE: 1.1694

RIG_SCORE: 0.7473

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K76N	TCGA-K4-A6MB	BLCA	TCGA	RREKLRQLM	DEG_APCC_DBOX_1	0.25
p.K76N	DO44077	BLCA	ICGC	RREKLRQLM	DEG_APCC_DBOX_1	0.25
p.E81K	DO229221	THCA	ICGC	RREKLRQLM	DEG_APCC_DBOX_1	0.2778
p.R78M	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	RREKLRQLM	DEG_APCC_DBOX_1	0.1944
p.R78M	ACH-000444	Lung Cancer	CCLE	RREKLRQLM	DEG_APCC_DBOX_1	0.1944
p.R78M	LU-99A	lung	COSMIC	RREKLRQLM	DEG_APCC_DBOX_1	0.1944
p.E93K	SIDM00934	Pancreatic Carcinoma	GDSC	RREKLRQLM	DEG_APCC_DBOX_1	0.2778
p.E93K	CAPAN-1	pancreas	COSMIC	RREKLRQLM	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BT92	Trichoplein keratin filament-binding protein	DEG_APCC_DBOX_1	83:91	RREKLRQLM	APC,CDC20,FZR1	0.627	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons