DegronMD

Uniprot ID: Q14517

Source protein: Protocadherin Fat 1

Source gene: FAT1

Class: DEG_APCC_DBOX_1

Location: 1267:1275

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9215

ASA_SCORE: 46.3333

COIL: 0.3206

CONS_SCORE: 0.4746

DSS_SCORE: 0.5697

HELIX: 0.0207

FCONS_SCORE: 0.9979

RIG_SCORE: 0.7515

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1278N	TCGA-2G-AAKD	TGCT	TCGA	RREPLYHVI	DEG_APCC_DBOX_1	0.25
p.D1278N	TCGA-A5-A1OF	UCEC	TCGA	RREPLYHVI	DEG_APCC_DBOX_1	0.25
p.D1278N	TCGA-EB-A551	SKCM	TCGA	RREPLYHVI	DEG_APCC_DBOX_1	0.25
p.D1278N	DO47453	SKCM	ICGC	RREPLYHVI	DEG_APCC_DBOX_1	0.25
p.D1278N	DO42568	UCEC	ICGC	RREPLYHVI	DEG_APCC_DBOX_1	0.25
p.D1278N	SIDM00193	Colorectal Carcinoma	GDSC	RREPLYHVI	DEG_APCC_DBOX_1	0.25
p.D1278N	ACH-000991	Colon/Colorectal Cancer	CCLE	RREPLYHVI	DEG_APCC_DBOX_1	0.25
p.D1278N	SNU-81	large_intestine	COSMIC	RREPLYHVI	DEG_APCC_DBOX_1	0.25
p.A1285T	TCGA-A6-3809	COAD	TCGA	RREPLYHVI	DEG_APCC_DBOX_1	0.0556
p.A1285T	DO8722	COAD	ICGC	RREPLYHVI	DEG_APCC_DBOX_1	0.0556
p.V1274I	TCGA-AP-A1DV	UCEC	TCGA	RREPLYHVI	DEG_APCC_DBOX_1	0.5965
p.V1274I	TCGA-AZ-6598	COAD	TCGA	RREPLYHVI	DEG_APCC_DBOX_1	0.5965
p.V1274I	DO10276	COAD	ICGC	RREPLYHVI	DEG_APCC_DBOX_1	0.5965
p.V1274I	DO43186	UCEC	ICGC	RREPLYHVI	DEG_APCC_DBOX_1	0.5965
p.V1274I	SIDM00032	Bladder Carcinoma	GDSC	RREPLYHVI	DEG_APCC_DBOX_1	0.5965
p.V1274I	ACH-000839	Bladder Cancer	CCLE	RREPLYHVI	DEG_APCC_DBOX_1	0.5965
p.V1274I	ACH-000872	Lung Cancer	CCLE	RREPLYHVI	DEG_APCC_DBOX_1	0.5965
p.R1262Q	TCGA-CD-A4MI	STAD	TCGA	RREPLYHVI	DEG_APCC_DBOX_1	0.1944
p.R1262Q	DO47717	STAD	ICGC	RREPLYHVI	DEG_APCC_DBOX_1	0.1944
p.R1268W	TCGA-DU-6392	LGG	TCGA	RREPLYHVI	DEG_APCC_DBOX_1	0.8634
p.R1268W	DO22237	LGG	ICGC	RREPLYHVI	DEG_APCC_DBOX_1	0.8634
p.R1268W	DO228346	MALY	ICGC	RREPLYHVI	DEG_APCC_DBOX_1	0.8634
p.H1273R	DO229010	COCA	ICGC	RREPLYHVI	DEG_APCC_DBOX_1	0.7133
p.H1273R	DO229013	COCA	ICGC	RREPLYHVI	DEG_APCC_DBOX_1	0.7133
p.H1273R	DO229016	COCA	ICGC	RREPLYHVI	DEG_APCC_DBOX_1	0.7133
p.H1273R	DO229003	COCA	ICGC	RREPLYHVI	DEG_APCC_DBOX_1	0.7133
p.H1273R	DO229005	COCA	ICGC	RREPLYHVI	DEG_APCC_DBOX_1	0.7133
p.H1273R	DO229480	LAML	ICGC	RREPLYHVI	DEG_APCC_DBOX_1	0.7133
p.H1273R	DO231114	LUSC	ICGC	RREPLYHVI	DEG_APCC_DBOX_1	0.7133
p.H1273R	DO233575	RECA	ICGC	RREPLYHVI	DEG_APCC_DBOX_1	0.7133
p.R1257Q	DO223038	ESCA	ICGC	RREPLYHVI	DEG_APCC_DBOX_1	0.0556
p.R1257Q	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	RREPLYHVI	DEG_APCC_DBOX_1	0.0556
p.R1257Q	SIDM01526	Mesothelioma	GDSC	RREPLYHVI	DEG_APCC_DBOX_1	0.0556
p.R1257Q	ACH-000086	Lung Cancer	CCLE	RREPLYHVI	DEG_APCC_DBOX_1	0.0556
p.R1257Q	ACH-000605	Esophageal Cancer	CCLE	RREPLYHVI	DEG_APCC_DBOX_1	0.0556
p.R1257Q	TE-6	oesophagus	COSMIC	RREPLYHVI	DEG_APCC_DBOX_1	0.0556
p.A1276D	DO229029	LICA	ICGC	RREPLYHVI	DEG_APCC_DBOX_1	0.3056
p.A1266D	DO229031	LICA	ICGC	RREPLYHVI	DEG_APCC_DBOX_1	0.3056
p.P1270A	DO231070	LUSC	ICGC	RREPLYHVI	DEG_APCC_DBOX_1	0.6392
p.A1276V	SIDM01259	B-Lymphoblastic Leukemia	GDSC	RREPLYHVI	DEG_APCC_DBOX_1	0.3056
p.A1276V	ACH-001669	Leukemia	CCLE	RREPLYHVI	DEG_APCC_DBOX_1	0.3056
p.A1276V	ACH-002238	Leukemia	CCLE	RREPLYHVI	DEG_APCC_DBOX_1	0.3056
p.A1276V	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	RREPLYHVI	DEG_APCC_DBOX_1	0.3056
p.H1273Y	SIDM00889	Cervical Carcinoma	GDSC	RREPLYHVI	DEG_APCC_DBOX_1	0.6118
p.H1273Y	ACH-001333	Cervical Cancer	CCLE	RREPLYHVI	DEG_APCC_DBOX_1	0.6118
p.H1273Y	C-33-A	cervix	COSMIC	RREPLYHVI	DEG_APCC_DBOX_1	0.6118
p.D1280Y	SIDM01018	Hodgkin's Lymphoma	GDSC	RREPLYHVI	DEG_APCC_DBOX_1	0.1944
p.D1280Y	ACH-000114	Pancreatic Cancer	CCLE	RREPLYHVI	DEG_APCC_DBOX_1	0.1944
p.D1280Y	ACH-000815	Lymphoma	CCLE	RREPLYHVI	DEG_APCC_DBOX_1	0.1944
p.D1280Y	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	RREPLYHVI	DEG_APCC_DBOX_1	0.1944
p.T1277I	SIDM01660	Kidney Carcinoma	GDSC	RREPLYHVI	DEG_APCC_DBOX_1	0.7222
p.T1277I	ACH-000709	Kidney Cancer	CCLE	RREPLYHVI	DEG_APCC_DBOX_1	0.7222
p.E1258K	ACH-002238	Leukemia	CCLE	RREPLYHVI	DEG_APCC_DBOX_1	0.0833
p.E1258K	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	RREPLYHVI	DEG_APCC_DBOX_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RREPLYHVI

Degron related mutations and impact score

Drug responses associated with FAT1 mutations

All proteins holding degron of RREPLYHVI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14517	Protocadherin Fat 1	DEG_APCC_DBOX_1	1267:1275	RREPLYHVI	APC,CDC20,FZR1	0.9215	More...