DegronMD

Uniprot ID: Q96ES7

Source protein: SAGA-associated factor 29

Source gene: SGF29

Class: DEG_APCC_DBOX_1

Location: 115:123

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6298

ASA_SCORE: 80.6556

COIL: 0.5027

CONS_SCORE: 0.4136

DSS_SCORE: 0.4328

HELIX: 0.4132

FCONS_SCORE: 1.1797

RIG_SCORE: 0.8287

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R115H	SIDM01058	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRGVLMTLL	DEG_APCC_DBOX_1	0.7133
p.R115H	GRANTA-519	haematopoietic_and_lymphoid_tissue	COSMIC	RRGVLMTLL	DEG_APCC_DBOX_1	0.7133
p.K112N	SIDM00099	Mesothelioma	GDSC	RRGVLMTLL	DEG_APCC_DBOX_1	0.3611
p.K112N	H2722	pleura	COSMIC	RRGVLMTLL	DEG_APCC_DBOX_1	0.3611

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96ES7	SAGA-associated factor 29	DEG_APCC_DBOX_1	115:123	RRGVLMTLL	APC,CDC20,FZR1	0.6298	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons