DegronMD

Uniprot ID: A0FGR9

Source protein: Extended synaptotagmin-3

Source gene: ESYT3

Class: DEG_APCC_DBOX_1

Location: 852:860

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6696

ASA_SCORE: 69.7556

COIL: 0.4223

CONS_SCORE: 0.3364

DSS_SCORE: 0.3118

HELIX: 0.0344

FCONS_SCORE: 0.9845

RIG_SCORE: 0.7844

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E866K	TCGA-CV-7568	HNSC	TCGA	RRKELGKVL	DEG_APCC_DBOX_1	0.1667
p.E866K	DO14160	HNSC	ICGC	RRKELGKVL	DEG_APCC_DBOX_1	0.1667
p.G857R	DO48367	BLCA	ICGC	RRKELGKVL	DEG_APCC_DBOX_1	0.6457
p.K843E	DO48687	LIRI	ICGC	RRKELGKVL	DEG_APCC_DBOX_1	0.1944
p.E866D	SIDM01175	Other Sarcomas	GDSC	RRKELGKVL	DEG_APCC_DBOX_1	0.1667
p.E866D	ACH-002309	Sarcoma	CCLE	RRKELGKVL	DEG_APCC_DBOX_1	0.1667
p.E866D	SW684	soft_tissue	COSMIC	RRKELGKVL	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0FGR9	Extended synaptotagmin-3	DEG_APCC_DBOX_1	852:860	RRKELGKVL	APC,CDC20,FZR1	0.6696	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons