DegronMD

Uniprot ID: P62906

Source protein: 60S ribosomal protein L10a

Source gene: RPL10A

Class: DEG_APCC_DBOX_1

Location: 25:33

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.717

ASA_SCORE: 78.1889

COIL: 0.5187

CONS_SCORE: 0.8162

DSS_SCORE: 0.3046

HELIX: 0.1379

FCONS_SCORE: 1.1584

RIG_SCORE: 0.847

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K27T	TCGA-D3-A5GU	SKCM	TCGA	RRKFLETVE	DEG_APCC_DBOX_1	0.6195
p.L38F	TCGA-EM-A3AQ	THCA	TCGA	RRKFLETVE	DEG_APCC_DBOX_1	0.1944
p.L38F	DO40484	THCA	ICGC	RRKFLETVE	DEG_APCC_DBOX_1	0.1944
p.P43S	TCGA-TS-A7P6	MESO	TCGA	RRKFLETVE	DEG_APCC_DBOX_1	0.0556
p.P43H	TCGA-VQ-A8P2	STAD	TCGA	RRKFLETVE	DEG_APCC_DBOX_1	0.0556
p.P43H	DO51761	STAD	ICGC	RRKFLETVE	DEG_APCC_DBOX_1	0.0556
p.D42H	DO225004	BRCA	ICGC	RRKFLETVE	DEG_APCC_DBOX_1	0.0833
p.R25H	DO6394	CLLE	ICGC	RRKFLETVE	DEG_APCC_DBOX_1	0.7133
p.G20W	DO231215	LAML	ICGC	RRKFLETVE	DEG_APCC_DBOX_1	0.1944
p.V17G	DO50760	LICA	ICGC	RRKFLETVE	DEG_APCC_DBOX_1	0.1111
p.S37T	DO27855	MALY	ICGC	RRKFLETVE	DEG_APCC_DBOX_1	0.2222
p.N40K	SU-DHL-5	haematopoietic_and_lymphoid_tissue	COSMIC	RRKFLETVE	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P62906	60S ribosomal protein L10a	DEG_APCC_DBOX_1	25:33	RRKFLETVE	APC,CDC20,FZR1	0.717	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons