DegronMD

Uniprot ID: Q96A11

Source protein: Galactose-3-O-sulfotransferase 3

Source gene: GAL3ST3

Class: DEG_APCC_DBOX_1

Location: 17:25

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7945

ASA_SCORE: 83.0222

COIL: 0.0216

CONS_SCORE: 0.5624

DSS_SCORE: 0.0333

HELIX: 0.9764

FCONS_SCORE: 1.4833

RIG_SCORE: 0.9248

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A11D	TCGA-66-2755	LUSC	TCGA	RRKILLLVL	DEG_APCC_DBOX_1	0.1667
p.A11D	DO27365	LUSC	ICGC	RRKILLLVL	DEG_APCC_DBOX_1	0.1667
p.L33I	TCGA-AN-A046	BRCA	TCGA	RRKILLLVL	DEG_APCC_DBOX_1	0.1111
p.L33I	TCGA-F5-6814	READ	TCGA	RRKILLLVL	DEG_APCC_DBOX_1	0.1111
p.L33I	DO1285	BRCA	ICGC	RRKILLLVL	DEG_APCC_DBOX_1	0.1111
p.L33I	DO36556	READ	ICGC	RRKILLLVL	DEG_APCC_DBOX_1	0.1111
p.H35Q	DO229018	LICA	ICGC	RRKILLLVL	DEG_APCC_DBOX_1	0.0556
p.S28R	DO229257	THCA	ICGC	RRKILLLVL	DEG_APCC_DBOX_1	0.25
p.I34T	DO229242	THCA	ICGC	RRKILLLVL	DEG_APCC_DBOX_1	0.0833
p.V30A	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	RRKILLLVL	DEG_APCC_DBOX_1	0.1944
p.V30A	ACH-000924	Lung Cancer	CCLE	RRKILLLVL	DEG_APCC_DBOX_1	0.1944
p.V30A	NCI-H2172	lung	COSMIC	RRKILLLVL	DEG_APCC_DBOX_1	0.1944
p.L23P	SIDM01003	T-Lymphoblastic Leukemia	GDSC	RRKILLLVL	DEG_APCC_DBOX_1	0.6471
p.L23P	ACH-000101	Leukemia	CCLE	RRKILLLVL	DEG_APCC_DBOX_1	0.6471
p.L23P	KE-37	haematopoietic_and_lymphoid_tissue	COSMIC	RRKILLLVL	DEG_APCC_DBOX_1	0.6471
p.K19N	ACH-001280	Sarcoma	CCLE	RRKILLLVL	DEG_APCC_DBOX_1	0.5806

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96A11	Galactose-3-O-sulfotransferase 3	DEG_APCC_DBOX_1	17:25	RRKILLLVL	APC,CDC20,FZR1	0.7945	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons