DegronMD

Uniprot ID: Q6X4W1

Source protein: NMDA receptor synaptonuclear signaling and neuronal migration factor

Source gene: NSMF

Class: DEG_APCC_DBOX_1

Location: 195:203

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8814

ASA_SCORE: 105.8556

COIL: 0.4394

CONS_SCORE: 0.5287

DSS_SCORE: 0.4902

HELIX: 0.5163

FCONS_SCORE: 1.1365

RIG_SCORE: 0.7422

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R196H	TCGA-06-0648	GBM	TCGA	RRKKLERMY	DEG_APCC_DBOX_1	0.8244
p.R196H	DO11022	GBM	ICGC	RRKKLERMY	DEG_APCC_DBOX_1	0.8244
p.R201S	TCGA-58-8386	LUSC	TCGA	RRKKLERMY	DEG_APCC_DBOX_1	0.6316
p.R201S	DO45537	LUSC	ICGC	RRKKLERMY	DEG_APCC_DBOX_1	0.6316
p.R207C	TCGA-B5-A3FC	UCEC	TCGA	RRKKLERMY	DEG_APCC_DBOX_1	0.2222
p.R207C	DO41871	UCEC	ICGC	RRKKLERMY	DEG_APCC_DBOX_1	0.2222
p.R195H	TCGA-FI-A2D5	UCEC	TCGA	RRKKLERMY	DEG_APCC_DBOX_1	0.7133
p.R195H	DO41331	UCEC	ICGC	RRKKLERMY	DEG_APCC_DBOX_1	0.7133
p.G198A	DO15238	HNSC	ICGC	RRKKLERMY	DEG_APCC_DBOX_1	0.754
p.N193H	DO223831	KIRC	ICGC	RRKKLERMY	DEG_APCC_DBOX_1	0.2778
p.S204R	DO229031	LICA	ICGC	RRKKLERMY	DEG_APCC_DBOX_1	0.75
p.V205I	SIDM00997	Thyroid Gland Carcinoma	GDSC	RRKKLERMY	DEG_APCC_DBOX_1	0.2778
p.V205I	ACH-001306	Thyroid Cancer	CCLE	RRKKLERMY	DEG_APCC_DBOX_1	0.2778
p.V205I	8305C	thyroid	COSMIC	RRKKLERMY	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6X4W1	NMDA receptor synaptonuclear signaling and neuronal migration factor	DEG_APCC_DBOX_1	195:203	RRKKLERMY	APC,CDC20,FZR1	0.8814	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons