DegronMD

Uniprot ID: Q92888

Source protein: Rho guanine nucleotide exchange factor 1

Source gene: ARHGEF1

Class: DEG_APCC_DBOX_1

Location: 620:628

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.731

ASA_SCORE: 79.1444

COIL: 0.4526

CONS_SCORE: 0.4798

DSS_SCORE: 0.2791

HELIX: 0.5164

FCONS_SCORE: 1.023

RIG_SCORE: 0.7596

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E625D	TCGA-AJ-A3BH	UCEC	TCGA	RRLDLSHLR	DEG_APCC_DBOX_1	0.6758
p.R622C	TCGA-QG-A5Z2	COAD	TCGA	RRLDLSHLR	DEG_APCC_DBOX_1	0.8301
p.R622C	ACH-001610	Brain Cancer	CCLE	RRLDLSHLR	DEG_APCC_DBOX_1	0.8301
p.R622S	TCGA-VS-A9UO	CESC	TCGA	RRLDLSHLR	DEG_APCC_DBOX_1	0.7427
p.Q629H	DO48386	BLCA	ICGC	RRLDLSHLR	DEG_APCC_DBOX_1	0.3056
p.L621P	DO222492	COCA	ICGC	RRLDLSHLR	DEG_APCC_DBOX_1	0.7582
p.S618I	DO228974	LICA	ICGC	RRLDLSHLR	DEG_APCC_DBOX_1	0.2778
p.G634V	DO229035	LICA	ICGC	RRLDLSHLR	DEG_APCC_DBOX_1	0.1667
p.K621N	DO26445	LUSC	ICGC	RRLDLSHLR	DEG_APCC_DBOX_1	0.6918
p.L637P	SIDM01951	Colorectal Carcinoma	GDSC	RRLDLSHLR	DEG_APCC_DBOX_1	0.0833
p.R636C	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRLDLSHLR	DEG_APCC_DBOX_1	0.1111
p.R636C	ACH-002272	Lymphoma	CCLE	RRLDLSHLR	DEG_APCC_DBOX_1	0.1111
p.R636C	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	RRLDLSHLR	DEG_APCC_DBOX_1	0.1111
p.L614V	ACH-001677	Lymphoma	CCLE	RRLDLSHLR	DEG_APCC_DBOX_1	0.1667
p.G632R	HEC-1	endometrium	COSMIC	RRLDLSHLR	DEG_APCC_DBOX_1	0.2222
p.R621C	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	RRLDLSHLR	DEG_APCC_DBOX_1	0.8301
p.T616M	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	RRLDLSHLR	DEG_APCC_DBOX_1	0.3333
p.R620W	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	RRLDLSHLR	DEG_APCC_DBOX_1	0.7523
p.K627T	LN-229	central_nervous_system	COSMIC	RRLDLSHLR	DEG_APCC_DBOX_1	0.7306

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92888	Rho guanine nucleotide exchange factor 1	DEG_APCC_DBOX_1	620:628	RRLDLSHLR	APC,CDC20,FZR1	0.731	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons