DegronMD - Q92888(ARHGEF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P562Q	TCGA-18-3414	LUSC	TCGA	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.2222
p.P562L	TCGA-A5-A0VP	UCEC	TCGA	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.2222
p.P562L	TCGA-HU-8602	STAD	TCGA	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.2222
p.G32D	TCGA-A8-A09Z	BRCA	TCGA	SRPGLVPVS	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.0556
p.G32D	DO5521	BRCA	ICGC	SRPGLVPVS	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.0556
p.E625D	TCGA-AJ-A3BH	UCEC	TCGA	RRLDLSHLR	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.6758
p.R563Q	TCGA-AP-A1DH	UCEC	TCGA	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.1944
p.R561H	TCGA-AP-A1DK	UCEC	TCGA	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.25
p.R565H	TCGA-AU-6004	COAD	TCGA	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.1389
p.A543T	TCGA-BG-A222	UCEC	TCGA	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.1389
p.V555M	TCGA-BR-8591	STAD	TCGA	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation altering degron motif	0.7208
p.P26L	TCGA-CK-4951	COAD	TCGA	SRPGLVPVS	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.2222
p.P26L	DO10582	COAD	ICGC	SRPGLVPVS	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.2222
p.Q568L	TCGA-CR-7364	HNSC	TCGA	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.0556
p.R21P	TCGA-DK-A3IU	BLCA	TCGA	SRPGLVPVS	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.7512
p.R21P	DO612	BLCA	ICGC	SRPGLVPVS	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.7512
p.R566H	TCGA-F7-A50J	HNSC	TCGA	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.1111
p.R30Q	TCGA-PG-A6IB	UCEC	TCGA	SRPGLVPVS	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1111
p.R30Q	DO52419	UCEC	ICGC	SRPGLVPVS	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1111
p.R622C	TCGA-QG-A5Z2	COAD	TCGA	RRLDLSHLR	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.8301
p.R622C	ACH-001610	Brain Cancer	CCLE	RRLDLSHLR	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.8301
p.R622S	TCGA-VS-A9UO	CESC	TCGA	RRLDLSHLR	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.7427
p.R21Q	TCGA-ZF-AA4W	BLCA	TCGA	SRPGLVPVS	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.7329
p.R21Q	DO219089	BLCA	ICGC	SRPGLVPVS	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.7329
p.R21Q	SIDM00607	Glioblastoma	GDSC	SRPGLVPVS	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.7329
p.R21Q	KNS-42	central nervous system	COSMIC	SRPGLVPVS	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.7329
p.Q629H	DO48386	BLCA	ICGC	RRLDLSHLR	DEG_APCC_DBOX_1	620:628	Mutation rewiring degron network	0.3056
p.E563K	DO767	BLCA	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.1944
p.F564Y	DO10582	COAD	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.1667
p.Y550C	DO230326	COCA	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation altering degron motif	0.7087
p.L621P	DO222492	COCA	ICGC	RRLDLSHLR	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.7582
p.R551H	DO44431	HNSC	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation altering degron motif	0.8244
p.R551H	DO228419	MALY	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation altering degron motif	0.8244
p.S618I	DO228974	LICA	ICGC	RRLDLSHLR	DEG_APCC_DBOX_1	620:628	Mutation rewiring degron network	0.2778
p.G561V	DO228971	LICA	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.25
p.G32C	DO229015	LICA	ICGC	SRPGLVPVS	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.0556
p.G32C	DO229031	LICA	ICGC	SRPGLVPVS	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.0556
p.V551L	DO229036	LICA	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation altering degron motif	0.6765
p.G634V	DO229035	LICA	ICGC	RRLDLSHLR	DEG_APCC_DBOX_1	620:628	Mutation rewiring degron network	0.1667
p.G558W	DO26959	LUSC	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation altering degron motif	0.7825
p.G558W	DO37444	SKCM	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation altering degron motif	0.7825
p.K621N	DO26445	LUSC	ICGC	RRLDLSHLR	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.6918
p.V551M	DO46657	PAAD	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation altering degron motif	0.7208
p.V551M	SNU-175	large intestine	COSMIC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation altering degron motif	0.7208
p.L547M	DO37643	SKCM	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.25
p.L547M	DO50279	SKCM	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.25
p.R567L	DO37511	SKCM	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation blocking ubiquitination signal	0.5278
p.T565K	DO219787	UCEC	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.1389
p.G558R	DO41871	UCEC	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation altering degron motif	0.7568
p.G558R	HEC-1	endometrium	COSMIC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation altering degron motif	0.7568
p.L637P	SIDM01951	Colorectal Carcinoma	GDSC	RRLDLSHLR	DEG_APCC_DBOX_1	620:628	Mutation rewiring degron network	0.0833
p.A11T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	SRPGLVPVS	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.25
p.A11T	ACH-000981	Leukemia	CCLE	SRPGLVPVS	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.25
p.A11T	DND-41	haematopoietic and lymphoid tissue	COSMIC	SRPGLVPVS	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.25
p.R636C	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRLDLSHLR	DEG_APCC_DBOX_1	620:628	Mutation rewiring degron network	0.1111
p.R636C	ACH-002272	Lymphoma	CCLE	RRLDLSHLR	DEG_APCC_DBOX_1	620:628	Mutation rewiring degron network	0.1111
p.R636C	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	RRLDLSHLR	DEG_APCC_DBOX_1	620:628	Mutation rewiring degron network	0.1111
p.R566C	SIDM00596	Endometrial Carcinoma	GDSC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.1111
p.R566C	ACH-000941	Endometrial/Uterine Cancer	CCLE	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.1111
p.R566C	ACH-000954	Endometrial/Uterine Cancer	CCLE	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.1111
p.R566C	ACH-001517	Endometrial/Uterine Cancer	CCLE	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.1111
p.R566C	HEC-1	endometrium	COSMIC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.1111
p.R563W	SIDM00217	Colorectal Carcinoma	GDSC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.1944
p.R563W	ACH-000999	Colon/Colorectal Cancer	CCLE	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.1944
p.R563W	SNU-1040	large intestine	COSMIC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.1944
p.R546H	ACH-001675	Head and Neck Cancer	CCLE	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.2222
p.L614V	ACH-001677	Lymphoma	CCLE	RRLDLSHLR	DEG_APCC_DBOX_1	620:628	Mutation rewiring degron network	0.1667
p.G632R	HEC-1	endometrium	COSMIC	RRLDLSHLR	DEG_APCC_DBOX_1	620:628	Mutation rewiring degron network	0.2222
p.R564W	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.1667
p.R6Q	KNS-42	central nervous system	COSMIC	SRPGLVPVS	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.1111
p.R548W	SNU-1040	large intestine	COSMIC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.2778
p.R621C	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	RRLDLSHLR	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.8301
p.T542M	CTV-1	haematopoietic and lymphoid tissue	COSMIC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.1111
p.T616M	CTV-1	haematopoietic and lymphoid tissue	COSMIC	RRLDLSHLR	DEG_APCC_DBOX_1	620:628	Mutation substituting flanking lysine	0.3333
p.R551C	HEC-1	endometrium	COSMIC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation altering degron motif	0.8301
p.R546W	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.2222
p.R620W	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	RRLDLSHLR	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.7523
p.K627T	LN-229	central nervous system	COSMIC	RRLDLSHLR	DEG_APCC_DBOX_1	620:628	Mutation altering degron motif	0.7306
p.T560M	CTV-1	haematopoietic and lymphoid tissue	COSMIC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.2778
p.G543R	HEC-1	endometrium	COSMIC	RRLQLKDMI	DEG_APCC_DBOX_1	550:558	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGEF1

UniProt ID: Q92888

Entrez ID: 9138

Protein name: Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGEF1 in