DegronMD

Uniprot ID: Q92888

Source protein: Rho guanine nucleotide exchange factor 1

Source gene: ARHGEF1

Class: DEG_APCC_DBOX_1

Location: 550:558

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7796

ASA_SCORE: 83.2111

COIL: 0.5728

CONS_SCORE: 0.6087

DSS_SCORE: 0.444

HELIX: 0.381

FCONS_SCORE: 1.0007

RIG_SCORE: 0.8028

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P562Q	TCGA-18-3414	LUSC	TCGA	RRLQLKDMI	DEG_APCC_DBOX_1	0.2222
p.P562L	TCGA-A5-A0VP	UCEC	TCGA	RRLQLKDMI	DEG_APCC_DBOX_1	0.2222
p.P562L	TCGA-HU-8602	STAD	TCGA	RRLQLKDMI	DEG_APCC_DBOX_1	0.2222
p.R563Q	TCGA-AP-A1DH	UCEC	TCGA	RRLQLKDMI	DEG_APCC_DBOX_1	0.1944
p.R561H	TCGA-AP-A1DK	UCEC	TCGA	RRLQLKDMI	DEG_APCC_DBOX_1	0.25
p.R565H	TCGA-AU-6004	COAD	TCGA	RRLQLKDMI	DEG_APCC_DBOX_1	0.1389
p.A543T	TCGA-BG-A222	UCEC	TCGA	RRLQLKDMI	DEG_APCC_DBOX_1	0.1389
p.V555M	TCGA-BR-8591	STAD	TCGA	RRLQLKDMI	DEG_APCC_DBOX_1	0.7208
p.Q568L	TCGA-CR-7364	HNSC	TCGA	RRLQLKDMI	DEG_APCC_DBOX_1	0.0556
p.R566H	TCGA-F7-A50J	HNSC	TCGA	RRLQLKDMI	DEG_APCC_DBOX_1	0.1111
p.E563K	DO767	BLCA	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	0.1944
p.F564Y	DO10582	COAD	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	0.1667
p.Y550C	DO230326	COCA	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	0.7087
p.R551H	DO44431	HNSC	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	0.8244
p.R551H	DO228419	MALY	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	0.8244
p.G561V	DO228971	LICA	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	0.25
p.V551L	DO229036	LICA	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	0.6765
p.G558W	DO26959	LUSC	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	0.7825
p.G558W	DO37444	SKCM	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	0.7825
p.V551M	DO46657	PAAD	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	0.7208
p.V551M	SNU-175	large_intestine	COSMIC	RRLQLKDMI	DEG_APCC_DBOX_1	0.7208
p.L547M	DO37643	SKCM	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	0.25
p.L547M	DO50279	SKCM	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	0.25
p.R567L	DO37511	SKCM	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	0.5278
p.T565K	DO219787	UCEC	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	0.1389
p.G558R	DO41871	UCEC	ICGC	RRLQLKDMI	DEG_APCC_DBOX_1	0.7568
p.G558R	HEC-1	endometrium	COSMIC	RRLQLKDMI	DEG_APCC_DBOX_1	0.7568
p.R566C	SIDM00596	Endometrial Carcinoma	GDSC	RRLQLKDMI	DEG_APCC_DBOX_1	0.1111
p.R566C	ACH-000941	Endometrial/Uterine Cancer	CCLE	RRLQLKDMI	DEG_APCC_DBOX_1	0.1111
p.R566C	ACH-000954	Endometrial/Uterine Cancer	CCLE	RRLQLKDMI	DEG_APCC_DBOX_1	0.1111
p.R566C	ACH-001517	Endometrial/Uterine Cancer	CCLE	RRLQLKDMI	DEG_APCC_DBOX_1	0.1111
p.R566C	HEC-1	endometrium	COSMIC	RRLQLKDMI	DEG_APCC_DBOX_1	0.1111
p.R563W	SIDM00217	Colorectal Carcinoma	GDSC	RRLQLKDMI	DEG_APCC_DBOX_1	0.1944
p.R563W	ACH-000999	Colon/Colorectal Cancer	CCLE	RRLQLKDMI	DEG_APCC_DBOX_1	0.1944
p.R563W	SNU-1040	large_intestine	COSMIC	RRLQLKDMI	DEG_APCC_DBOX_1	0.1944
p.R546H	ACH-001675	Head and Neck Cancer	CCLE	RRLQLKDMI	DEG_APCC_DBOX_1	0.2222
p.R564W	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	RRLQLKDMI	DEG_APCC_DBOX_1	0.1667
p.R548W	SNU-1040	large_intestine	COSMIC	RRLQLKDMI	DEG_APCC_DBOX_1	0.2778
p.T542M	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	RRLQLKDMI	DEG_APCC_DBOX_1	0.1111
p.R551C	HEC-1	endometrium	COSMIC	RRLQLKDMI	DEG_APCC_DBOX_1	0.8301
p.R546W	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	RRLQLKDMI	DEG_APCC_DBOX_1	0.2222
p.T560M	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	RRLQLKDMI	DEG_APCC_DBOX_1	0.2778
p.G543R	HEC-1	endometrium	COSMIC	RRLQLKDMI	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRLQLKDMI

Degron related mutations and impact score

Drug responses associated with ARHGEF1 mutations

All proteins holding degron of RRLQLKDMI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92888	Rho guanine nucleotide exchange factor 1	DEG_APCC_DBOX_1	550:558	RRLQLKDMI	APC,CDC20,FZR1	0.7796	More...