DegronMD

Uniprot ID: Q92888

Source protein: Rho guanine nucleotide exchange factor 1

Source gene: ARHGEF1

Class: DEG_APCC_DBOX_1

Location: 14:22

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9934

ASA_SCORE: 78.4222

COIL: 0.8913

CONS_SCORE: 0.2441

DSS_SCORE: 0.5921

HELIX: 0.0139

FCONS_SCORE: 0.942

RIG_SCORE: 0.6502

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G32D	TCGA-A8-A09Z	BRCA	TCGA	SRPGLVPVS	DEG_APCC_DBOX_1	0.0556
p.G32D	DO5521	BRCA	ICGC	SRPGLVPVS	DEG_APCC_DBOX_1	0.0556
p.P26L	TCGA-CK-4951	COAD	TCGA	SRPGLVPVS	DEG_APCC_DBOX_1	0.2222
p.P26L	DO10582	COAD	ICGC	SRPGLVPVS	DEG_APCC_DBOX_1	0.2222
p.R21P	TCGA-DK-A3IU	BLCA	TCGA	SRPGLVPVS	DEG_APCC_DBOX_1	0.7512
p.R21P	DO612	BLCA	ICGC	SRPGLVPVS	DEG_APCC_DBOX_1	0.7512
p.R30Q	TCGA-PG-A6IB	UCEC	TCGA	SRPGLVPVS	DEG_APCC_DBOX_1	0.1111
p.R30Q	DO52419	UCEC	ICGC	SRPGLVPVS	DEG_APCC_DBOX_1	0.1111
p.R21Q	TCGA-ZF-AA4W	BLCA	TCGA	SRPGLVPVS	DEG_APCC_DBOX_1	0.7329
p.R21Q	DO219089	BLCA	ICGC	SRPGLVPVS	DEG_APCC_DBOX_1	0.7329
p.R21Q	SIDM00607	Glioblastoma	GDSC	SRPGLVPVS	DEG_APCC_DBOX_1	0.7329
p.R21Q	KNS-42	central_nervous_system	COSMIC	SRPGLVPVS	DEG_APCC_DBOX_1	0.7329
p.G32C	DO229015	LICA	ICGC	SRPGLVPVS	DEG_APCC_DBOX_1	0.0556
p.G32C	DO229031	LICA	ICGC	SRPGLVPVS	DEG_APCC_DBOX_1	0.0556
p.A11T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	SRPGLVPVS	DEG_APCC_DBOX_1	0.25
p.A11T	ACH-000981	Leukemia	CCLE	SRPGLVPVS	DEG_APCC_DBOX_1	0.25
p.A11T	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	SRPGLVPVS	DEG_APCC_DBOX_1	0.25
p.R6Q	KNS-42	central_nervous_system	COSMIC	SRPGLVPVS	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92888	Rho guanine nucleotide exchange factor 1	DEG_APCC_DBOX_1	14:22	SRPGLVPVS	APC,CDC20,FZR1	0.9934	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons