DegronMD

Uniprot ID: O43399

Source protein: Tumor protein D54

Source gene: TPD52L2

Class: DEG_APCC_DBOX_1

Location: 79:87

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.944

ASA_SCORE: 64.3778

COIL: 0.4787

CONS_SCORE: 0.7398

DSS_SCORE: 0.2292

HELIX: 0.4981

FCONS_SCORE: 1.1924

RIG_SCORE: 0.792

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S84F	TCGA-D8-A1XJ	BRCA	TCGA	RRLGLSTLG	DEG_APCC_DBOX_1	0.7982
p.S84F	SIDM00185	Melanoma	GDSC	RRLGLSTLG	DEG_APCC_DBOX_1	0.7982
p.S84F	SIDM01650	Non-Cancerous	GDSC	RRLGLSTLG	DEG_APCC_DBOX_1	0.7982
p.S84F	ACH-002354	Non-Cancerous	CCLE	RRLGLSTLG	DEG_APCC_DBOX_1	0.7982
p.S81R	HCC1954	breast	COSMIC	RRLGLSTLG	DEG_APCC_DBOX_1	0.7427
p.S81G	WM793B	skin	COSMIC	RRLGLSTLG	DEG_APCC_DBOX_1	0.6993
p.G87E	TCGA-2W-A8YY	CESC	TCGA	RRLGLSTLG	DEG_APCC_DBOX_1	0.6087
p.V77L	DO231788	LINC	ICGC	RRLGLSTLG	DEG_APCC_DBOX_1	0.2778
p.T89P	NCI-H1304	lung	COSMIC	RRLGLSTLG	DEG_APCC_DBOX_1	0.2778
p.Q92H	DO228952	LICA	ICGC	RRLGLSTLG	DEG_APCC_DBOX_1	0.1944
p.A93T	DO233218	GACA	ICGC	RRLGLSTLG	DEG_APCC_DBOX_1	0.1667
p.S73I	DO232224	PBCA	ICGC	RRLGLSTLG	DEG_APCC_DBOX_1	0.1667
p.Q95R	DO42745	UCEC	ICGC	RRLGLSTLG	DEG_APCC_DBOX_1	0.1111

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43399	Tumor protein D54	DEG_APCC_DBOX_1	79:87	RRLGLSTLG	APC,CDC20,FZR1	0.944	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons