DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
RRLGLSTLG
Uniprot ID:
O43399
Source protein:
Tumor protein D54
Source gene:
TPD52L2
Class:
DEG_APCC_DBOX_1
Location:
79:87
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.944
ASA_SCORE:
64.3778
COIL:
0.4787
CONS_SCORE:
0.7398
DSS_SCORE:
0.2292
HELIX:
0.4981
FCONS_SCORE:
1.1924
RIG_SCORE:
0.792
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G87E
TCGA-2W-A8YY
CESC
TCGA
RRLGLSTLG
DEG_APCC_DBOX_1
0.6087
p.S84F
TCGA-D8-A1XJ
BRCA
TCGA
RRLGLSTLG
DEG_APCC_DBOX_1
0.7982
p.S84F
SIDM00185
Melanoma
GDSC
RRLGLSTLG
DEG_APCC_DBOX_1
0.7982
p.S84F
SIDM01650
Non-Cancerous
GDSC
RRLGLSTLG
DEG_APCC_DBOX_1
0.7982
p.S84F
ACH-002354
Non-Cancerous
CCLE
RRLGLSTLG
DEG_APCC_DBOX_1
0.7982
p.A93T
DO233218
GACA
ICGC
RRLGLSTLG
DEG_APCC_DBOX_1
0.1667
p.Q92H
DO228952
LICA
ICGC
RRLGLSTLG
DEG_APCC_DBOX_1
0.1944
p.V77L
DO231788
LINC
ICGC
RRLGLSTLG
DEG_APCC_DBOX_1
0.2778
p.S73I
DO232224
PBCA
ICGC
RRLGLSTLG
DEG_APCC_DBOX_1
0.1667
p.Q95R
DO42745
UCEC
ICGC
RRLGLSTLG
DEG_APCC_DBOX_1
0.1111
p.S81G
WM793B
skin
COSMIC
RRLGLSTLG
DEG_APCC_DBOX_1
0.6993
p.T89P
NCI-H1304
lung
COSMIC
RRLGLSTLG
DEG_APCC_DBOX_1
0.2778
p.S81R
HCC1954
breast
COSMIC
RRLGLSTLG
DEG_APCC_DBOX_1
0.7427
Drug responses associated with TPD52L2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RRLGLSTLG
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O43399
Tumor protein D54
DEG_APCC_DBOX_1
79:87
RRLGLSTLG
APC,CDC20,FZR1
0.944
More...