DegronMD

Uniprot ID: Q9BXM0

Source protein: Periaxin

Source gene: PRX

Class: DEG_APCC_DBOX_1

Location: 186:194

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9152

ASA_SCORE: 106.7556

COIL: 0.8644

CONS_SCORE: 0.8667

DSS_SCORE: 0.4303

HELIX: 0.0371

FCONS_SCORE: 1.0027

RIG_SCORE: 0.7773

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R187C	TCGA-42-2593	OV	TCGA	RRLQLPRLR	DEG_APCC_DBOX_1	0.8301
p.R187C	DO28329	OV	ICGC	RRLQLPRLR	DEG_APCC_DBOX_1	0.8301
p.P178T	TCGA-DD-A73D	LIHC	TCGA	RRLQLPRLR	DEG_APCC_DBOX_1	0.1111
p.P178T	DO48528	LIHC	ICGC	RRLQLPRLR	DEG_APCC_DBOX_1	0.1111
p.E200K	DO8264	COAD	ICGC	RRLQLPRLR	DEG_APCC_DBOX_1	0.1667
p.R194H	DO230312	COCA	ICGC	RRLQLPRLR	DEG_APCC_DBOX_1	0.7133
p.R185H	DO233089	GACA	ICGC	RRLQLPRLR	DEG_APCC_DBOX_1	0.3056
p.R185H	SIDM00967	Ovarian Carcinoma	GDSC	RRLQLPRLR	DEG_APCC_DBOX_1	0.3056
p.R187H	DO33091	PACA	ICGC	RRLQLPRLR	DEG_APCC_DBOX_1	0.8244
p.R192Q	DO51953	PRAD	ICGC	RRLQLPRLR	DEG_APCC_DBOX_1	0.6218
p.P180S	DO47331	SKCM	ICGC	RRLQLPRLR	DEG_APCC_DBOX_1	0.1667
p.P180L	DO38535	STAD	ICGC	RRLQLPRLR	DEG_APCC_DBOX_1	0.1667
p.A199V	DO229211	THCA	ICGC	RRLQLPRLR	DEG_APCC_DBOX_1	0.1944
p.R194C	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	RRLQLPRLR	DEG_APCC_DBOX_1	0.719

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXM0	Periaxin	DEG_APCC_DBOX_1	186:194	RRLQLPRLR	APC,CDC20,FZR1	0.9152	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons