DegronMD

Uniprot ID: Q86UX6

Source protein: Serine/threonine-protein kinase 32C

Source gene: STK32C

Class: LIG_APCC_ABBAyCdc20_2

Location: 78:84

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8962

ASA_SCORE: 111.9

COIL: 0.9029

CONS_SCORE: 0.3055

DSS_SCORE: 0.3543

HELIX: 0.0404

FCONS_SCORE: 0.7933

RIG_SCORE: 0.7857

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q94L	TCGA-38-4626	LUAD	TCGA	RRPVFDD	LIG_APCC_ABBAyCdc20_2	0.0556
p.D91Y	TCGA-55-1592	LUAD	TCGA	RRPVFDD	LIG_APCC_ABBAyCdc20_2	0.1389
p.D91N	TCGA-A5-A2K5	UCEC	TCGA	RRPVFDD	LIG_APCC_ABBAyCdc20_2	0.1389
p.A72V	DO220828	BRCA	ICGC	RRPVFDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.G92D	DO3686	BRCA	ICGC	RRPVFDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.E73K	DO51624	CESC	ICGC	RRPVFDD	LIG_APCC_ABBAyCdc20_2	0.1944
p.V69M	DO222765	COCA	ICGC	RRPVFDD	LIG_APCC_ABBAyCdc20_2	0.0833
p.A68D	DO229008	LICA	ICGC	RRPVFDD	LIG_APCC_ABBAyCdc20_2	0.0556
p.A86T	DO50970	LICA	ICGC	RRPVFDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E73D	DO45183	LIRI	ICGC	RRPVFDD	LIG_APCC_ABBAyCdc20_2	0.1944
p.E73D	DO41572	UCEC	ICGC	RRPVFDD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D88Y	DO23629	LUAD	ICGC	RRPVFDD	LIG_APCC_ABBAyCdc20_2	0.2222
p.G92E	DO49083	LUSC	ICGC	RRPVFDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.N68D	DO36369	PRAD	ICGC	RRPVFDD	LIG_APCC_ABBAyCdc20_2	0.0556
p.L90M	DO47623	SKCM	ICGC	RRPVFDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R91C	DO223286	UCEC	ICGC	RRPVFDD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R91C	DO42633	UCEC	ICGC	RRPVFDD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R91C	ACH-000994	Endometrial/Uterine Cancer	CCLE	RRPVFDD	LIG_APCC_ABBAyCdc20_2	0.1389
p.G70R	DO42977	UCEC	ICGC	RRPVFDD	LIG_APCC_ABBAyCdc20_2	0.5556
p.K85R	SIDM00953	Small Cell Lung Carcinoma	GDSC	RRPVFDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.K85R	CPC-N	lung	COSMIC	RRPVFDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.T76N	SIDM00632	Non-Cancerous	GDSC	RRPVFDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.T76N	IM-9	haematopoietic_and_lymphoid_tissue	COSMIC	RRPVFDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.L85V	ACH-000994	Endometrial/Uterine Cancer	CCLE	RRPVFDD	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UX6	Serine/threonine-protein kinase 32C	LIG_APCC_ABBAyCdc20_2	78:84	RRPVFDD	APC,CDC20,FZR1	0.8962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRPVFDD

Degron related mutations and impact score

Drug responses associated with STK32C mutations

All proteins holding degron of RRPVFDD