DegronMD

Uniprot ID: Q8TF44

Source protein: C2 calcium-dependent domain-containing protein 4C

Source gene: C2CD4C

Class: LIG_APCC_ABBAyCdc20_2

Location: 367:373

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5752

ASA_SCORE: 78.8143

COIL: 0.8941

CONS_SCORE: 0.7911

DSS_SCORE: 0.1557

HELIX: 0.0081

FCONS_SCORE: 1.3166

RIG_SCORE: 0.8216

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R359H	DO222973	BTCA	ICGC	RRPVFNE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R359H	ACH-001518	Endometrial/Uterine Cancer	CCLE	RRPVFNE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G379S	DO233652	GACA	ICGC	RRPVFNE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R368C	DO233764	GACA	ICGC	RRPVFNE	LIG_APCC_ABBAyCdc20_2	0.719
p.F371L	DO229041	LICA	ICGC	RRPVFNE	LIG_APCC_ABBAyCdc20_2	0.6981
p.N372K	DO229041	LICA	ICGC	RRPVFNE	LIG_APCC_ABBAyCdc20_2	0.5806
p.R367H	ACH-000956	Prostate Cancer	CCLE	RRPVFNE	LIG_APCC_ABBAyCdc20_2	0.8244
p.A383S	ACH-001529	Endometrial/Uterine Cancer	CCLE	RRPVFNE	LIG_APCC_ABBAyCdc20_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TF44	C2 calcium-dependent domain-containing protein 4C	LIG_APCC_ABBAyCdc20_2	367:373	RRPVFNE	APC,CDC20,FZR1	0.5752	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons