DegronMD

Uniprot ID: Q9ULL0

Source protein: Acrosomal protein KIAA1210

Source gene: KIAA1210

Class: DEG_APCC_DBOX_1

Location: 309:317

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9993

ASA_SCORE: 123.8889

COIL: 0.9411

CONS_SCORE: 0.4169

DSS_SCORE: 0.4431

HELIX: 0.0311

FCONS_SCORE: 1.4115

RIG_SCORE: 0.7694

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R310L	TCGA-AG-A002	READ	TCGA	RRRRLSIIP	DEG_APCC_DBOX_1	0.8428
p.R310Q	TCGA-EO-A3B0	UCEC	TCGA	RRRRLSIIP	DEG_APCC_DBOX_1	0.7329
p.R310Q	DO219773	UCEC	ICGC	RRRRLSIIP	DEG_APCC_DBOX_1	0.7329
p.R309C	SIDM01424	B-Lymphoblastic Leukemia	GDSC	RRRRLSIIP	DEG_APCC_DBOX_1	0.719
p.R309H	TCGA-69-7979	LUAD	TCGA	RRRRLSIIP	DEG_APCC_DBOX_1	0.7133
p.R309H	TCGA-HU-A4GC	STAD	TCGA	RRRRLSIIP	DEG_APCC_DBOX_1	0.7133
p.R309H	DO23874	LUAD	ICGC	RRRRLSIIP	DEG_APCC_DBOX_1	0.7133
p.R309H	DO47797	STAD	ICGC	RRRRLSIIP	DEG_APCC_DBOX_1	0.7133
p.R309H	SIDM00162	Biliary Tract Carcinoma	GDSC	RRRRLSIIP	DEG_APCC_DBOX_1	0.7133
p.R309H	ACH-000268	Bile Duct Cancer	CCLE	RRRRLSIIP	DEG_APCC_DBOX_1	0.7133
p.R311H	TCGA-EO-A22R	UCEC	TCGA	RRRRLSIIP	DEG_APCC_DBOX_1	0.7133
p.R311H	DO42713	UCEC	ICGC	RRRRLSIIP	DEG_APCC_DBOX_1	0.7133
p.R311P	TCGA-43-8115	LUSC	TCGA	RRRRLSIIP	DEG_APCC_DBOX_1	0.6401
p.R311P	DO26440	LUSC	ICGC	RRRRLSIIP	DEG_APCC_DBOX_1	0.6401
p.R312Q	DO52387	LUSC	ICGC	RRRRLSIIP	DEG_APCC_DBOX_1	0.6218
p.P317S	TCGA-D3-A51T	SKCM	TCGA	RRRRLSIIP	DEG_APCC_DBOX_1	0.5641
p.P317S	DO47389	SKCM	ICGC	RRRRLSIIP	DEG_APCC_DBOX_1	0.5641
p.P317S	SIDM00770	Small Cell Lung Carcinoma	GDSC	RRRRLSIIP	DEG_APCC_DBOX_1	0.5641
p.P317S	ACH-000559	Lung Cancer	CCLE	RRRRLSIIP	DEG_APCC_DBOX_1	0.5641
p.P317S	NCI-H1836	lung	COSMIC	RRRRLSIIP	DEG_APCC_DBOX_1	0.5641
p.S326Y	TCGA-AX-A05Z	UCEC	TCGA	RRRRLSIIP	DEG_APCC_DBOX_1	0.0833
p.S326Y	TCGA-AX-A2HC	UCEC	TCGA	RRRRLSIIP	DEG_APCC_DBOX_1	0.0833
p.S326Y	DO40884	UCEC	ICGC	RRRRLSIIP	DEG_APCC_DBOX_1	0.0833
p.S326Y	DO41572	UCEC	ICGC	RRRRLSIIP	DEG_APCC_DBOX_1	0.0833
p.G299D	TCGA-GM-A2DA	BRCA	TCGA	RRRRLSIIP	DEG_APCC_DBOX_1	0.0556

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Drug responses associated with KIAA1210 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of RRRRLSIIP

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULL0	Acrosomal protein KIAA1210	DEG_APCC_DBOX_1	309:317	RRRRLSIIP	APC,CDC20,FZR1	0.9993	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRRRLSIIP

Degron related mutations and impact score

Drug responses associated with KIAA1210 mutations

All proteins holding degron of RRRRLSIIP