DegronMD

Uniprot ID: Q9ULL0

Source protein: Acrosomal protein KIAA1210

Source gene: KIAA1210

Class: DEG_APCC_DBOX_1

Location: 309:317

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9993

ASA_SCORE: 123.8889

COIL: 0.9411

CONS_SCORE: 0.4169

DSS_SCORE: 0.4431

HELIX: 0.0311

FCONS_SCORE: 1.4115

RIG_SCORE: 0.7694

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R311P	TCGA-43-8115	LUSC	TCGA	RRRRLSIIP	DEG_APCC_DBOX_1	0.6401
p.R311P	DO26440	LUSC	ICGC	RRRRLSIIP	DEG_APCC_DBOX_1	0.6401
p.R309H	TCGA-69-7979	LUAD	TCGA	RRRRLSIIP	DEG_APCC_DBOX_1	0.7133
p.R309H	TCGA-HU-A4GC	STAD	TCGA	RRRRLSIIP	DEG_APCC_DBOX_1	0.7133
p.R309H	DO23874	LUAD	ICGC	RRRRLSIIP	DEG_APCC_DBOX_1	0.7133
p.R309H	DO47797	STAD	ICGC	RRRRLSIIP	DEG_APCC_DBOX_1	0.7133
p.R309H	SIDM00162	Biliary Tract Carcinoma	GDSC	RRRRLSIIP	DEG_APCC_DBOX_1	0.7133
p.R309H	ACH-000268	Bile Duct Cancer	CCLE	RRRRLSIIP	DEG_APCC_DBOX_1	0.7133
p.R310L	TCGA-AG-A002	READ	TCGA	RRRRLSIIP	DEG_APCC_DBOX_1	0.8428
p.S326Y	TCGA-AX-A05Z	UCEC	TCGA	RRRRLSIIP	DEG_APCC_DBOX_1	0.0833
p.S326Y	TCGA-AX-A2HC	UCEC	TCGA	RRRRLSIIP	DEG_APCC_DBOX_1	0.0833
p.S326Y	DO40884	UCEC	ICGC	RRRRLSIIP	DEG_APCC_DBOX_1	0.0833
p.S326Y	DO41572	UCEC	ICGC	RRRRLSIIP	DEG_APCC_DBOX_1	0.0833
p.P317S	TCGA-D3-A51T	SKCM	TCGA	RRRRLSIIP	DEG_APCC_DBOX_1	0.5641
p.P317S	DO47389	SKCM	ICGC	RRRRLSIIP	DEG_APCC_DBOX_1	0.5641
p.P317S	SIDM00770	Small Cell Lung Carcinoma	GDSC	RRRRLSIIP	DEG_APCC_DBOX_1	0.5641
p.P317S	ACH-000559	Lung Cancer	CCLE	RRRRLSIIP	DEG_APCC_DBOX_1	0.5641
p.P317S	NCI-H1836	lung	COSMIC	RRRRLSIIP	DEG_APCC_DBOX_1	0.5641
p.R311H	TCGA-EO-A22R	UCEC	TCGA	RRRRLSIIP	DEG_APCC_DBOX_1	0.7133
p.R311H	DO42713	UCEC	ICGC	RRRRLSIIP	DEG_APCC_DBOX_1	0.7133
p.R310Q	TCGA-EO-A3B0	UCEC	TCGA	RRRRLSIIP	DEG_APCC_DBOX_1	0.7329
p.R310Q	DO219773	UCEC	ICGC	RRRRLSIIP	DEG_APCC_DBOX_1	0.7329
p.G299D	TCGA-GM-A2DA	BRCA	TCGA	RRRRLSIIP	DEG_APCC_DBOX_1	0.0556
p.G299D	DO4569	BRCA	ICGC	RRRRLSIIP	DEG_APCC_DBOX_1	0.0556
p.G299D	SIDM00282	Colorectal Carcinoma	GDSC	RRRRLSIIP	DEG_APCC_DBOX_1	0.0556
p.G299D	ACH-000998	Colon/Colorectal Cancer	CCLE	RRRRLSIIP	DEG_APCC_DBOX_1	0.0556
p.G299D	CW-2	large_intestine	COSMIC	RRRRLSIIP	DEG_APCC_DBOX_1	0.0556
p.R312Q	DO52387	LUSC	ICGC	RRRRLSIIP	DEG_APCC_DBOX_1	0.6218
p.R309C	SIDM01424	B-Lymphoblastic Leukemia	GDSC	RRRRLSIIP	DEG_APCC_DBOX_1	0.719

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRRRLSIIP

Degron related mutations and impact score

Drug responses associated with KIAA1210 mutations

All proteins holding degron of RRRRLSIIP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULL0	Acrosomal protein KIAA1210	DEG_APCC_DBOX_1	309:317	RRRRLSIIP	APC,CDC20,FZR1	0.9993	More...