DegronMD

Uniprot ID: Q96QZ7

Source protein: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

Source gene: MAGI1

Class: DEG_APCC_DBOX_1

Location: 1399:1407

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9558

ASA_SCORE: 118.1

COIL: 0.4947

CONS_SCORE: 0.1767

DSS_SCORE: 0.6826

HELIX: 0.4884

FCONS_SCORE: 1.0079

RIG_SCORE: 0.6481

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1403H	TCGA-22-4609	LUSC	TCGA	RRRSLERLL	DEG_APCC_DBOX_1	0.8244
p.R1403H	DO26838	LUSC	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.8244
p.D1400Y	TCGA-43-2581	LUSC	TCGA	RRRSLERLL	DEG_APCC_DBOX_1	0.7325
p.D1400Y	DO26602	LUSC	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.7325
p.S1406F	TCGA-90-A4ED	LUSC	TCGA	RRRSLERLL	DEG_APCC_DBOX_1	0.7982
p.S1406F	DO45482	LUSC	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.7982
p.R1413W	TCGA-AX-A2HD	UCEC	TCGA	RRRSLERLL	DEG_APCC_DBOX_1	0.1667
p.R1413W	DO42608	UCEC	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.1667
p.R1405C	TCGA-B5-A0JZ	UCEC	TCGA	RRRSLERLL	DEG_APCC_DBOX_1	0.719
p.R1405C	DO42761	UCEC	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.719
p.E1408K	TCGA-BR-8081	STAD	TCGA	RRRSLERLL	DEG_APCC_DBOX_1	0.3056
p.E1408K	DO23308	LINC	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.3056
p.E1408K	DO38795	STAD	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.3056
p.R1413L	TCGA-CG-4305	STAD	TCGA	RRRSLERLL	DEG_APCC_DBOX_1	0.1667
p.R1413L	DO38823	STAD	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.1667
p.R1403C	TCGA-CG-4305	STAD	TCGA	RRRSLERLL	DEG_APCC_DBOX_1	0.8301
p.R1403C	DO38823	STAD	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.8301
p.R1401Q	TCGA-EC-A24G	UCEC	TCGA	RRRSLERLL	DEG_APCC_DBOX_1	0.6218
p.R1401Q	DO40996	UCEC	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.6218
p.G1389E	DO225223	BRCA	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.5
p.R1405H	DO230326	COCA	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.7133
p.R1405H	DO222769	COCA	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.7133
p.R1409H	DO233737	GACA	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.2778
p.A1396D	DO228974	LICA	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.25
p.D1416E	DO229024	LICA	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.0833
p.R1394C	DO228138	PBCA	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.1944
p.R1394C	SIDM00217	Colorectal Carcinoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	0.1944
p.R1394C	SNU-1040	large_intestine	COSMIC	RRRSLERLL	DEG_APCC_DBOX_1	0.1944
p.D1400N	SIDM01314	Colorectal Carcinoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	0.6932
p.R1405G	SIDM01261	Breast Carcinoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	0.6457
p.R1405G	SIDM00314	Breast Carcinoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	0.6457
p.R1405G	ACH-000097	Breast Cancer	CCLE	RRRSLERLL	DEG_APCC_DBOX_1	0.6457
p.R1405G	ACH-002208	Breast Cancer	CCLE	RRRSLERLL	DEG_APCC_DBOX_1	0.6457
p.R1405G	YMB-1-E	breast	COSMIC	RRRSLERLL	DEG_APCC_DBOX_1	0.6457
p.R1394H	SIDM00602	Gastric Carcinoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	0.1944
p.R1394H	IM-95	stomach	COSMIC	RRRSLERLL	DEG_APCC_DBOX_1	0.1944
p.A1404P	SIDM00741	Small Cell Lung Carcinoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	0.7503
p.A1404P	ACH-000431	Lung Cancer	CCLE	RRRSLERLL	DEG_APCC_DBOX_1	0.7503
p.A1404P	NCI-H1694	lung	COSMIC	RRRSLERLL	DEG_APCC_DBOX_1	0.7503
p.S1391L	SIDM01146	Gastric Carcinoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	0.1111
p.S1391L	NCI-SNU-1	stomach	COSMIC	RRRSLERLL	DEG_APCC_DBOX_1	0.1111
p.G1390D	SIDM00217	Colorectal Carcinoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	0.0833
p.G1390D	ACH-000999	Colon/Colorectal Cancer	CCLE	RRRSLERLL	DEG_APCC_DBOX_1	0.0833
p.G1390D	SNU-1040	large_intestine	COSMIC	RRRSLERLL	DEG_APCC_DBOX_1	0.0833
p.A1396T	SIDM00274	Gastric Carcinoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	0.25
p.A1396T	ACH-000047	Gastric Cancer	CCLE	RRRSLERLL	DEG_APCC_DBOX_1	0.25
p.A1396T	ACH-002025	Colon/Colorectal Cancer	CCLE	RRRSLERLL	DEG_APCC_DBOX_1	0.25
p.A1396T	GCIY	stomach	COSMIC	RRRSLERLL	DEG_APCC_DBOX_1	0.25
p.R1395S	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	0.6667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRRSLERLL

Degron related mutations and impact score

Drug responses associated with MAGI1 mutations

All proteins holding degron of RRRSLERLL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96QZ7	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1	DEG_APCC_DBOX_1	1399:1407	RRRSLERLL	APC,CDC20,FZR1	0.9558	More...