DegronMD

Uniprot ID: Q96QZ7

Source protein: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

Source gene: MAGI1

Class: DEG_APCC_DBOX_1

Location: 1399:1407

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9558

ASA_SCORE: 118.1

COIL: 0.4947

CONS_SCORE: 0.1767

DSS_SCORE: 0.6826

HELIX: 0.4884

FCONS_SCORE: 1.0079

RIG_SCORE: 0.6481

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1403C	TCGA-CG-4305	STAD	TCGA	RRRSLERLL	DEG_APCC_DBOX_1	0.8301
p.R1403C	DO38823	STAD	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.8301
p.R1403H	TCGA-22-4609	LUSC	TCGA	RRRSLERLL	DEG_APCC_DBOX_1	0.8244
p.R1403H	DO26838	LUSC	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.8244
p.S1406F	TCGA-90-A4ED	LUSC	TCGA	RRRSLERLL	DEG_APCC_DBOX_1	0.7982
p.S1406F	DO45482	LUSC	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.7982
p.A1404P	SIDM00741	Small Cell Lung Carcinoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	0.7503
p.A1404P	ACH-000431	Lung Cancer	CCLE	RRRSLERLL	DEG_APCC_DBOX_1	0.7503
p.A1404P	NCI-H1694	lung	COSMIC	RRRSLERLL	DEG_APCC_DBOX_1	0.7503
p.D1400Y	TCGA-43-2581	LUSC	TCGA	RRRSLERLL	DEG_APCC_DBOX_1	0.7325
p.D1400Y	DO26602	LUSC	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.7325
p.R1405C	TCGA-B5-A0JZ	UCEC	TCGA	RRRSLERLL	DEG_APCC_DBOX_1	0.719
p.R1405C	DO42761	UCEC	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.719
p.R1405H	DO230326	COCA	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.7133
p.R1405H	DO222769	COCA	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.7133
p.D1400N	SIDM01314	Colorectal Carcinoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	0.6932
p.R1395S	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	0.6667
p.R1405G	SIDM01261	Breast Carcinoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	0.6457
p.R1405G	SIDM00314	Breast Carcinoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	0.6457
p.R1405G	ACH-000097	Breast Cancer	CCLE	RRRSLERLL	DEG_APCC_DBOX_1	0.6457
p.R1405G	ACH-002208	Breast Cancer	CCLE	RRRSLERLL	DEG_APCC_DBOX_1	0.6457
p.R1405G	YMB-1-E	breast	COSMIC	RRRSLERLL	DEG_APCC_DBOX_1	0.6457
p.R1401Q	TCGA-EC-A24G	UCEC	TCGA	RRRSLERLL	DEG_APCC_DBOX_1	0.6218
p.R1401Q	DO40996	UCEC	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.6218
p.G1389E	DO225223	BRCA	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	0.5

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Drug responses associated with MAGI1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of RRRSLERLL

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96QZ7	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1	DEG_APCC_DBOX_1	1399:1407	RRRSLERLL	APC,CDC20,FZR1	0.9558	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRRSLERLL

Degron related mutations and impact score

Drug responses associated with MAGI1 mutations

All proteins holding degron of RRRSLERLL