DegronMD - Q96QZ7(MAGI1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1403H	TCGA-22-4609	LUSC	TCGA	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation altering degron motif	0.8244
p.R1403H	DO26838	LUSC	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation altering degron motif	0.8244
p.D1400Y	TCGA-43-2581	LUSC	TCGA	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation altering degron motif	0.7325
p.D1400Y	DO26602	LUSC	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation altering degron motif	0.7325
p.S1406F	TCGA-90-A4ED	LUSC	TCGA	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation altering degron motif	0.7982
p.S1406F	DO45482	LUSC	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation altering degron motif	0.7982
p.R1413W	TCGA-AX-A2HD	UCEC	TCGA	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation rewiring degron network	0.1667
p.R1413W	DO42608	UCEC	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation rewiring degron network	0.1667
p.T940M	TCGA-AY-6197	COAD	TCGA	TENEVPSP	DEG_COP1_1	932:939	Mutation rewiring degron network	0.3056
p.T940M	SIDM00999	Bladder Carcinoma	GDSC	TENEVPSP	DEG_COP1_1	932:939	Mutation rewiring degron network	0.3056
p.T940M	ACH-000973	Bladder Cancer	CCLE	TENEVPSP	DEG_COP1_1	932:939	Mutation rewiring degron network	0.3056
p.T940M	639-V	urinary tract	COSMIC	TENEVPSP	DEG_COP1_1	932:939	Mutation rewiring degron network	0.3056
p.E926D	TCGA-AZ-4615	COAD	TCGA	TENEVPSP	DEG_COP1_1	932:939	Mutation rewiring degron network	0.1667
p.R1405C	TCGA-B5-A0JZ	UCEC	TCGA	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation altering degron motif	0.719
p.R1405C	DO42761	UCEC	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation altering degron motif	0.719
p.E1408K	TCGA-BR-8081	STAD	TCGA	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation rewiring degron network	0.3056
p.E1408K	DO23308	LINC	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation rewiring degron network	0.3056
p.E1408K	DO38795	STAD	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation rewiring degron network	0.3056
p.R1413L	TCGA-CG-4305	STAD	TCGA	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation rewiring degron network	0.1667
p.R1413L	DO38823	STAD	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation rewiring degron network	0.1667
p.R1403C	TCGA-CG-4305	STAD	TCGA	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation altering degron motif	0.8301
p.R1403C	DO38823	STAD	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation altering degron motif	0.8301
p.R1401Q	TCGA-EC-A24G	UCEC	TCGA	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation altering degron motif	0.6218
p.R1401Q	DO40996	UCEC	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation altering degron motif	0.6218
p.S937T	TCGA-EE-A2MU	SKCM	TCGA	TENEVPSP	DEG_COP1_1	932:939	Mutation altering degron motif	0.7116
p.R929H	TCGA-K4-A3WU	BLCA	TCGA	TENEVPSP	DEG_COP1_1	932:939	Mutation rewiring degron network	0.25
p.S949R	TCGA-LP-A5U3	CESC	TCGA	TENEVPSP	DEG_COP1_1	932:939	Mutation rewiring degron network	0.0556
p.G1389E	DO225223	BRCA	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation blocking phosphorylation signal	0.5
p.R1405H	DO230326	COCA	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation altering degron motif	0.7133
p.R1405H	DO222769	COCA	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation altering degron motif	0.7133
p.R1409H	DO233737	GACA	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation rewiring degron network	0.2778
p.S938L	DO44445	HNSC	ICGC	TENEVPSP	DEG_COP1_1	932:939	Mutation altering degron motif	0.7667
p.A1396D	DO228974	LICA	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation rewiring degron network	0.25
p.D1416E	DO229024	LICA	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation rewiring degron network	0.0833
p.N934K	DO229008	LICA	ICGC	TENEVPSP	DEG_COP1_1	932:939	Mutation altering degron motif	0.5806
p.P937S	DO23354	LINC	ICGC	TENEVPSP	DEG_COP1_1	932:939	Mutation altering degron motif	0.6752
p.A928V	DO23308	LINC	ICGC	TENEVPSP	DEG_COP1_1	932:939	Mutation rewiring degron network	0.2222
p.A928V	DO26766	LUSC	ICGC	TENEVPSP	DEG_COP1_1	932:939	Mutation rewiring degron network	0.2222
p.A928E	DO23516	LIRI	ICGC	TENEVPSP	DEG_COP1_1	932:939	Mutation rewiring degron network	0.2222
p.E935K	DO222532	MELA	ICGC	TENEVPSP	DEG_COP1_1	932:939	Mutation altering degron motif	0.591
p.R1394C	DO228138	PBCA	ICGC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation rewiring degron network	0.1944
p.R1394C	SIDM00217	Colorectal Carcinoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation rewiring degron network	0.1944
p.R1394C	SNU-1040	large intestine	COSMIC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation rewiring degron network	0.1944
p.E933K	DO37831	SKCM	ICGC	TENEVPSP	DEG_COP1_1	932:939	Mutation altering degron motif	0.7022
p.N934S	DO42023	UCEC	ICGC	TENEVPSP	DEG_COP1_1	932:939	Mutation altering degron motif	0.5958
p.P949S	DO41752	UCEC	ICGC	TENEVPSP	DEG_COP1_1	932:939	Mutation rewiring degron network	0.0556
p.D1400N	SIDM01314	Colorectal Carcinoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation altering degron motif	0.6932
p.R929C	SIDM00958	Chronic Myelogenous Leukemia	GDSC	TENEVPSP	DEG_COP1_1	932:939	Mutation rewiring degron network	0.25
p.R929C	ACH-000920	Leukemia	CCLE	TENEVPSP	DEG_COP1_1	932:939	Mutation rewiring degron network	0.25
p.R929C	CML-T1	haematopoietic and lymphoid tissue	COSMIC	TENEVPSP	DEG_COP1_1	932:939	Mutation rewiring degron network	0.25
p.R1405G	SIDM01261	Breast Carcinoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation altering degron motif	0.6457
p.R1405G	SIDM00314	Breast Carcinoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation altering degron motif	0.6457
p.R1405G	ACH-000097	Breast Cancer	CCLE	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation altering degron motif	0.6457
p.R1405G	ACH-002208	Breast Cancer	CCLE	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation altering degron motif	0.6457
p.R1405G	YMB-1-E	breast	COSMIC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation altering degron motif	0.6457
p.R1394H	SIDM00602	Gastric Carcinoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation rewiring degron network	0.1944
p.R1394H	IM-95	stomach	COSMIC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation rewiring degron network	0.1944
p.P931L	SIDM01199	Hepatocellular Carcinoma	GDSC	TENEVPSP	DEG_COP1_1	932:939	Mutation rewiring degron network	0.3056
p.P931L	ACH-000493	Liver Cancer	CCLE	TENEVPSP	DEG_COP1_1	932:939	Mutation rewiring degron network	0.3056
p.P931L	SNU-423	liver	COSMIC	TENEVPSP	DEG_COP1_1	932:939	Mutation rewiring degron network	0.3056
p.A1404P	SIDM00741	Small Cell Lung Carcinoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation altering degron motif	0.7503
p.A1404P	ACH-000431	Lung Cancer	CCLE	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation altering degron motif	0.7503
p.A1404P	NCI-H1694	lung	COSMIC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation altering degron motif	0.7503
p.S943L	SIDM01093	Cervical Carcinoma	GDSC	TENEVPSP	DEG_COP1_1	932:939	Mutation rewiring degron network	0.2222
p.S943L	ACH-000556	Cervical Cancer	CCLE	TENEVPSP	DEG_COP1_1	932:939	Mutation rewiring degron network	0.2222
p.S1391L	SIDM01146	Gastric Carcinoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation rewiring degron network	0.1111
p.S1391L	NCI-SNU-1	stomach	COSMIC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation rewiring degron network	0.1111
p.G1390D	SIDM00217	Colorectal Carcinoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation rewiring degron network	0.0833
p.G1390D	ACH-000999	Colon/Colorectal Cancer	CCLE	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation rewiring degron network	0.0833
p.G1390D	SNU-1040	large intestine	COSMIC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation rewiring degron network	0.0833
p.P931R	SIDM00579	Neuroblastoma	GDSC	TENEVPSP	DEG_COP1_1	932:939	Mutation rewiring degron network	0.3056
p.P931R	NB(TU)1-10	autonomic ganglia	COSMIC	TENEVPSP	DEG_COP1_1	932:939	Mutation rewiring degron network	0.3056
p.A1396T	SIDM00274	Gastric Carcinoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation rewiring degron network	0.25
p.A1396T	ACH-000047	Gastric Cancer	CCLE	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation rewiring degron network	0.25
p.A1396T	ACH-002025	Colon/Colorectal Cancer	CCLE	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation rewiring degron network	0.25
p.A1396T	GCIY	stomach	COSMIC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation rewiring degron network	0.25
p.L938P	SIDM00451	T-Lymphoblastic Leukemia	GDSC	TENEVPSP	DEG_COP1_1	932:939	Mutation altering degron motif	0.7582
p.L938P	ACH-000937	Leukemia	CCLE	TENEVPSP	DEG_COP1_1	932:939	Mutation altering degron motif	0.7582
p.L938P	PF-382	haematopoietic and lymphoid tissue	COSMIC	TENEVPSP	DEG_COP1_1	932:939	Mutation altering degron motif	0.7582
p.R1395S	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	RRRSLERLL	DEG_APCC_DBOX_1	1399:1407	Mutation blocking phosphorylation signal	0.6667
p.R923S	SKM-1	haematopoietic and lymphoid tissue	COSMIC	TENEVPSP	DEG_COP1_1	932:939	Mutation rewiring degron network	0.0833
p.D942N	PF-382	haematopoietic and lymphoid tissue	COSMIC	TENEVPSP	DEG_COP1_1	932:939	Mutation rewiring degron network	0.25
p.P927L	COLO-679	skin	COSMIC	TENEVPSP	DEG_COP1_1	932:939	Mutation rewiring degron network	0.1944
p.N938K	Daudi	haematopoietic and lymphoid tissue	COSMIC	TENEVPSP	DEG_COP1_1	932:939	Mutation altering degron motif	0.6918
p.N938K	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	TENEVPSP	DEG_COP1_1	932:939	Mutation altering degron motif	0.6918
p.A933V	HCT-15	large intestine	COSMIC	TENEVPSP	DEG_COP1_1	932:939	Mutation altering degron motif	0.6936
p.I935T	HPAC	pancreas	COSMIC	TENEVPSP	DEG_COP1_1	932:939	Mutation altering degron motif	0.7078

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAGI1

UniProt ID: Q96QZ7

Entrez ID: 9223

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MAGI1 in