DegronMD

Uniprot ID: Q96QZ7

Source protein: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

Source gene: MAGI1

Class: DEG_COP1_1

Location: 932:939

E3 ligase: COP1

DEGRON score: 0.9248

ASA_SCORE: 92.75

COIL: 0.9279

CONS_SCORE: 0.2584

DSS_SCORE: 0.6117

HELIX: 0.0339

FCONS_SCORE: 0.9125

RIG_SCORE: 0.614

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T940M	TCGA-AY-6197	COAD	TCGA	TENEVPSP	DEG_COP1_1	0.3056
p.T940M	SIDM00999	Bladder Carcinoma	GDSC	TENEVPSP	DEG_COP1_1	0.3056
p.T940M	ACH-000973	Bladder Cancer	CCLE	TENEVPSP	DEG_COP1_1	0.3056
p.T940M	639-V	urinary_tract	COSMIC	TENEVPSP	DEG_COP1_1	0.3056
p.E926D	TCGA-AZ-4615	COAD	TCGA	TENEVPSP	DEG_COP1_1	0.1667
p.S937T	TCGA-EE-A2MU	SKCM	TCGA	TENEVPSP	DEG_COP1_1	0.7116
p.R929H	TCGA-K4-A3WU	BLCA	TCGA	TENEVPSP	DEG_COP1_1	0.25
p.S949R	TCGA-LP-A5U3	CESC	TCGA	TENEVPSP	DEG_COP1_1	0.0556
p.S938L	DO44445	HNSC	ICGC	TENEVPSP	DEG_COP1_1	0.7667
p.N934K	DO229008	LICA	ICGC	TENEVPSP	DEG_COP1_1	0.5806
p.P937S	DO23354	LINC	ICGC	TENEVPSP	DEG_COP1_1	0.6752
p.A928V	DO23308	LINC	ICGC	TENEVPSP	DEG_COP1_1	0.2222
p.A928V	DO26766	LUSC	ICGC	TENEVPSP	DEG_COP1_1	0.2222
p.A928E	DO23516	LIRI	ICGC	TENEVPSP	DEG_COP1_1	0.2222
p.E935K	DO222532	MELA	ICGC	TENEVPSP	DEG_COP1_1	0.591
p.E933K	DO37831	SKCM	ICGC	TENEVPSP	DEG_COP1_1	0.7022
p.N934S	DO42023	UCEC	ICGC	TENEVPSP	DEG_COP1_1	0.5958
p.P949S	DO41752	UCEC	ICGC	TENEVPSP	DEG_COP1_1	0.0556
p.R929C	SIDM00958	Chronic Myelogenous Leukemia	GDSC	TENEVPSP	DEG_COP1_1	0.25
p.R929C	ACH-000920	Leukemia	CCLE	TENEVPSP	DEG_COP1_1	0.25
p.R929C	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	TENEVPSP	DEG_COP1_1	0.25
p.P931L	SIDM01199	Hepatocellular Carcinoma	GDSC	TENEVPSP	DEG_COP1_1	0.3056
p.P931L	ACH-000493	Liver Cancer	CCLE	TENEVPSP	DEG_COP1_1	0.3056
p.P931L	SNU-423	liver	COSMIC	TENEVPSP	DEG_COP1_1	0.3056
p.S943L	SIDM01093	Cervical Carcinoma	GDSC	TENEVPSP	DEG_COP1_1	0.2222
p.S943L	ACH-000556	Cervical Cancer	CCLE	TENEVPSP	DEG_COP1_1	0.2222
p.P931R	SIDM00579	Neuroblastoma	GDSC	TENEVPSP	DEG_COP1_1	0.3056
p.P931R	NB(TU)1-10	autonomic_ganglia	COSMIC	TENEVPSP	DEG_COP1_1	0.3056
p.L938P	SIDM00451	T-Lymphoblastic Leukemia	GDSC	TENEVPSP	DEG_COP1_1	0.7582
p.L938P	ACH-000937	Leukemia	CCLE	TENEVPSP	DEG_COP1_1	0.7582
p.L938P	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	TENEVPSP	DEG_COP1_1	0.7582
p.R923S	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	TENEVPSP	DEG_COP1_1	0.0833
p.D942N	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	TENEVPSP	DEG_COP1_1	0.25
p.P927L	COLO-679	skin	COSMIC	TENEVPSP	DEG_COP1_1	0.1944
p.N938K	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	TENEVPSP	DEG_COP1_1	0.6918
p.N938K	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	TENEVPSP	DEG_COP1_1	0.6918
p.A933V	HCT-15	large_intestine	COSMIC	TENEVPSP	DEG_COP1_1	0.6936
p.I935T	HPAC	pancreas	COSMIC	TENEVPSP	DEG_COP1_1	0.7078

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TENEVPSP

Degron related mutations and impact score

Drug responses associated with MAGI1 mutations

All proteins holding degron of TENEVPSP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96QZ7	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1	DEG_COP1_1	932:939	TENEVPSP	COP1	0.9248	More...