DegronMD

Uniprot ID: Q99715

Source protein: Collagen alpha-1

Source gene: COL12A1

Class: DEG_APCC_DBOX_1

Location: 775:783

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9392

ASA_SCORE: 74.0556

COIL: 0.4853

CONS_SCORE: 0.4763

DSS_SCORE: 0.557

HELIX: 0.0067

FCONS_SCORE: 0.9047

RIG_SCORE: 0.7762

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P772S	TCGA-44-3917	LUAD	TCGA	RRRTLENLI	DEG_APCC_DBOX_1	0.25
p.P772S	DO25242	LUAD	ICGC	RRRTLENLI	DEG_APCC_DBOX_1	0.25
p.P784T	TCGA-AG-A002	READ	TCGA	RRRTLENLI	DEG_APCC_DBOX_1	0.3056
p.V790A	TCGA-B5-A1MW	UCEC	TCGA	RRRTLENLI	DEG_APCC_DBOX_1	0.1389
p.V790A	DO42913	UCEC	ICGC	RRRTLENLI	DEG_APCC_DBOX_1	0.1389
p.R776G	TCGA-BH-A1FC	BRCA	TCGA	RRRTLENLI	DEG_APCC_DBOX_1	0.7568
p.R776G	DO5661	BRCA	ICGC	RRRTLENLI	DEG_APCC_DBOX_1	0.7568
p.I793T	TCGA-ED-A7XO	LIHC	TCGA	RRRTLENLI	DEG_APCC_DBOX_1	0.0556
p.I793T	DO48496	LIHC	ICGC	RRRTLENLI	DEG_APCC_DBOX_1	0.0556
p.D785N	TCGA-EO-A22U	UCEC	TCGA	RRRTLENLI	DEG_APCC_DBOX_1	0.2778
p.D785N	DO43755	UCEC	ICGC	RRRTLENLI	DEG_APCC_DBOX_1	0.2778
p.V792I	SIDM01293	Colorectal Carcinoma	GDSC	RRRTLENLI	DEG_APCC_DBOX_1	0.0833
p.E789D	SIDM01175	Other Sarcomas	GDSC	RRRTLENLI	DEG_APCC_DBOX_1	0.1667
p.E789D	ACH-002309	Sarcoma	CCLE	RRRTLENLI	DEG_APCC_DBOX_1	0.1667
p.E789D	SW684	soft_tissue	COSMIC	RRRTLENLI	DEG_APCC_DBOX_1	0.1667
p.T769I	SIDM01149	Small Cell Lung Carcinoma	GDSC	RRRTLENLI	DEG_APCC_DBOX_1	0.1667
p.T769I	ACH-001365	Lung Cancer	CCLE	RRRTLENLI	DEG_APCC_DBOX_1	0.1667
p.T769I	NCI-H847	lung	COSMIC	RRRTLENLI	DEG_APCC_DBOX_1	0.1667
p.S765N	SIDM00683	Prostate Carcinoma	GDSC	RRRTLENLI	DEG_APCC_DBOX_1	0.5
p.S765N	ACH-000977	lymph_node	CCLE	RRRTLENLI	DEG_APCC_DBOX_1	0.5
p.S765N	LNCaP-Clone-FGC	prostate	COSMIC	RRRTLENLI	DEG_APCC_DBOX_1	0.5
p.D785Y	ACH-000769	Lung Cancer	CCLE	RRRTLENLI	DEG_APCC_DBOX_1	0.2778
p.P771R	ACH-000906	Ovarian Cancer	CCLE	RRRTLENLI	DEG_APCC_DBOX_1	0.2222
p.Y779N	COR-L88	lung	COSMIC	RRRTLENLI	DEG_APCC_DBOX_1	0.7059
p.V778A	COR-L88	lung	COSMIC	RRRTLENLI	DEG_APCC_DBOX_1	0.6936
p.P769L	NB14	autonomic_ganglia	COSMIC	RRRTLENLI	DEG_APCC_DBOX_1	0.1667
p.V777I	SNG-M	endometrium	COSMIC	RRRTLENLI	DEG_APCC_DBOX_1	0.7076

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRRTLENLI

Degron related mutations and impact score

Drug responses associated with COL12A1 mutations

All proteins holding degron of RRRTLENLI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99715	Collagen alpha-1	DEG_APCC_DBOX_1	775:783	RRRTLENLI	APC,CDC20,FZR1	0.9392	More...