DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
RRSALGDLA
Uniprot ID:
Q86XS8
Source protein:
E3 ubiquitin-protein ligase RNF130
Source gene:
RNF130
Class:
DEG_APCC_DBOX_1
Location:
339:347
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5194
ASA_SCORE:
81.9111
COIL:
0.7634
CONS_SCORE:
0.2989
DSS_SCORE:
0.4261
HELIX:
0.1311
FCONS_SCORE:
0.8844
RIG_SCORE:
0.7298
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G348C
TCGA-35-4122
LUAD
TCGA
RRSALGDLA
DEG_APCC_DBOX_1
0.3056
p.G348C
DO23782
LUAD
ICGC
RRSALGDLA
DEG_APCC_DBOX_1
0.3056
p.D345Y
TCGA-85-8580
LUSC
TCGA
RRSALGDLA
DEG_APCC_DBOX_1
0.6214
p.D345Y
DO45549
LUSC
ICGC
RRSALGDLA
DEG_APCC_DBOX_1
0.6214
p.R340I
TCGA-DU-7018
LGG
TCGA
RRSALGDLA
DEG_APCC_DBOX_1
0.8102
p.R340I
DO22223
LGG
ICGC
RRSALGDLA
DEG_APCC_DBOX_1
0.8102
p.T332I
TCGA-FR-A8YC
SKCM
TCGA
RRSALGDLA
DEG_APCC_DBOX_1
0.1389
p.T332I
DO50301
SKCM
ICGC
RRSALGDLA
DEG_APCC_DBOX_1
0.1389
p.G344S
TCGA-HP-A5N0
LIHC
TCGA
RRSALGDLA
DEG_APCC_DBOX_1
0.5882
p.G344S
DO52302
LIHC
ICGC
RRSALGDLA
DEG_APCC_DBOX_1
0.5882
p.G344S
DO228138
PBCA
ICGC
RRSALGDLA
DEG_APCC_DBOX_1
0.5882
p.G344S
SIDM00454
Rhabdomyosarcoma
GDSC
RRSALGDLA
DEG_APCC_DBOX_1
0.5882
p.G344S
SIDM00280
Gastric Carcinoma
GDSC
RRSALGDLA
DEG_APCC_DBOX_1
0.5882
p.G348S
DO51082
PRAD
ICGC
RRSALGDLA
DEG_APCC_DBOX_1
0.3056
p.A347T
DO42673
UCEC
ICGC
RRSALGDLA
DEG_APCC_DBOX_1
0.6028
p.A347V
SIDM00789
Colorectal Carcinoma
GDSC
RRSALGDLA
DEG_APCC_DBOX_1
0.5825
p.A347V
ACH-000997
Colon/Colorectal Cancer
CCLE
RRSALGDLA
DEG_APCC_DBOX_1
0.5825
p.A347V
HCT-15
large_intestine
COSMIC
RRSALGDLA
DEG_APCC_DBOX_1
0.5825
p.A347S
ACH-001458
Colon/Colorectal Cancer
CCLE
RRSALGDLA
DEG_APCC_DBOX_1
0.6477
Drug responses associated with RNF130 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RRSALGDLA
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86XS8
E3 ubiquitin-protein ligase RNF130
DEG_APCC_DBOX_1
339:347
RRSALGDLA
APC,CDC20,FZR1
0.5194
More...