DegronMD

Uniprot ID: Q86XS8

Source protein: E3 ubiquitin-protein ligase RNF130

Source gene: RNF130

Class: DEG_APCC_DBOX_1

Location: 339:347

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5194

ASA_SCORE: 81.9111

COIL: 0.7634

CONS_SCORE: 0.2989

DSS_SCORE: 0.4261

HELIX: 0.1311

FCONS_SCORE: 0.8844

RIG_SCORE: 0.7298

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R340I	TCGA-DU-7018	LGG	TCGA	RRSALGDLA	DEG_APCC_DBOX_1	0.8102
p.R340I	DO22223	LGG	ICGC	RRSALGDLA	DEG_APCC_DBOX_1	0.8102
p.A347S	ACH-001458	Colon/Colorectal Cancer	CCLE	RRSALGDLA	DEG_APCC_DBOX_1	0.6477
p.D345Y	TCGA-85-8580	LUSC	TCGA	RRSALGDLA	DEG_APCC_DBOX_1	0.6214
p.D345Y	DO45549	LUSC	ICGC	RRSALGDLA	DEG_APCC_DBOX_1	0.6214
p.A347T	DO42673	UCEC	ICGC	RRSALGDLA	DEG_APCC_DBOX_1	0.6028
p.G344S	TCGA-HP-A5N0	LIHC	TCGA	RRSALGDLA	DEG_APCC_DBOX_1	0.5882
p.G344S	DO52302	LIHC	ICGC	RRSALGDLA	DEG_APCC_DBOX_1	0.5882
p.G344S	DO228138	PBCA	ICGC	RRSALGDLA	DEG_APCC_DBOX_1	0.5882
p.G344S	SIDM00454	Rhabdomyosarcoma	GDSC	RRSALGDLA	DEG_APCC_DBOX_1	0.5882
p.G344S	SIDM00280	Gastric Carcinoma	GDSC	RRSALGDLA	DEG_APCC_DBOX_1	0.5882
p.A347V	SIDM00789	Colorectal Carcinoma	GDSC	RRSALGDLA	DEG_APCC_DBOX_1	0.5825
p.A347V	ACH-000997	Colon/Colorectal Cancer	CCLE	RRSALGDLA	DEG_APCC_DBOX_1	0.5825
p.A347V	HCT-15	large_intestine	COSMIC	RRSALGDLA	DEG_APCC_DBOX_1	0.5825
p.G348C	TCGA-35-4122	LUAD	TCGA	RRSALGDLA	DEG_APCC_DBOX_1	0.3056
p.G348C	DO23782	LUAD	ICGC	RRSALGDLA	DEG_APCC_DBOX_1	0.3056
p.G348S	DO51082	PRAD	ICGC	RRSALGDLA	DEG_APCC_DBOX_1	0.3056
p.T332I	TCGA-FR-A8YC	SKCM	TCGA	RRSALGDLA	DEG_APCC_DBOX_1	0.1389
p.T332I	DO50301	SKCM	ICGC	RRSALGDLA	DEG_APCC_DBOX_1	0.1389

Showing 1 to 19 of 19 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XS8	E3 ubiquitin-protein ligase RNF130	DEG_APCC_DBOX_1	339:347	RRSALGDLA	APC,CDC20,FZR1	0.5194	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons