DegronMD - Q86XS8(RNF130)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G348C	TCGA-35-4122	LUAD	TCGA	RRSALGDLA	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.3056
p.G348C	DO23782	LUAD	ICGC	RRSALGDLA	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.3056
p.D345Y	TCGA-85-8580	LUSC	TCGA	RRSALGDLA	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.6214
p.D345Y	DO45549	LUSC	ICGC	RRSALGDLA	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.6214
p.G182V	TCGA-AP-A0LM	UCEC	TCGA	SRGSLVFVS	DEG_APCC_DBOX_1	191:199	Mutation rewiring degron network	0.0833
p.G182V	DO43306	UCEC	ICGC	SRGSLVFVS	DEG_APCC_DBOX_1	191:199	Mutation rewiring degron network	0.0833
p.P186S	TCGA-AX-A06F	UCEC	TCGA	SRGSLVFVS	DEG_APCC_DBOX_1	191:199	Mutation rewiring degron network	0.1944
p.P186S	TCGA-QK-A8Z7	HNSC	TCGA	SRGSLVFVS	DEG_APCC_DBOX_1	191:199	Mutation rewiring degron network	0.1944
p.P186S	DO52096	HNSC	ICGC	SRGSLVFVS	DEG_APCC_DBOX_1	191:199	Mutation rewiring degron network	0.1944
p.P186S	DO41752	UCEC	ICGC	SRGSLVFVS	DEG_APCC_DBOX_1	191:199	Mutation rewiring degron network	0.1944
p.S209Y	TCGA-BS-A0UF	UCEC	TCGA	SRGSLVFVS	DEG_APCC_DBOX_1	191:199	Mutation blocking phosphorylation signal	0.5
p.S209Y	DO41488	UCEC	ICGC	SRGSLVFVS	DEG_APCC_DBOX_1	191:199	Mutation blocking phosphorylation signal	0.5
p.M185K	TCGA-CN-6024	HNSC	TCGA	SRGSLVFVS	DEG_APCC_DBOX_1	191:199	Mutation rewiring degron network	0.1667
p.M185K	DO15326	HNSC	ICGC	SRGSLVFVS	DEG_APCC_DBOX_1	191:199	Mutation rewiring degron network	0.1667
p.R340I	TCGA-DU-7018	LGG	TCGA	RRSALGDLA	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.8102
p.R340I	DO22223	LGG	ICGC	RRSALGDLA	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.8102
p.T332I	TCGA-FR-A8YC	SKCM	TCGA	RRSALGDLA	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.1389
p.T332I	DO50301	SKCM	ICGC	RRSALGDLA	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.1389
p.G344S	TCGA-HP-A5N0	LIHC	TCGA	RRSALGDLA	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.5882
p.G344S	DO52302	LIHC	ICGC	RRSALGDLA	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.5882
p.G344S	DO228138	PBCA	ICGC	RRSALGDLA	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.5882
p.G344S	SIDM00454	Rhabdomyosarcoma	GDSC	RRSALGDLA	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.5882
p.G344S	SIDM00280	Gastric Carcinoma	GDSC	RRSALGDLA	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.5882
p.P187L	DO222955	BTCA	ICGC	SRGSLVFVS	DEG_APCC_DBOX_1	191:199	Mutation rewiring degron network	0.2222
p.I208L	DO230313	COCA	ICGC	SRGSLVFVS	DEG_APCC_DBOX_1	191:199	Mutation rewiring degron network	0.0833
p.G348S	DO51082	PRAD	ICGC	RRSALGDLA	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.3056
p.A347T	DO42673	UCEC	ICGC	RRSALGDLA	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.6028
p.A347V	SIDM00789	Colorectal Carcinoma	GDSC	RRSALGDLA	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.5825
p.A347V	ACH-000997	Colon/Colorectal Cancer	CCLE	RRSALGDLA	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.5825
p.A347V	HCT-15	large intestine	COSMIC	RRSALGDLA	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.5825
p.A347S	ACH-001458	Colon/Colorectal Cancer	CCLE	RRSALGDLA	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.6477

Kaplan plot for RNF130 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RNF130

UniProt ID: Q86XS8

Entrez ID: 55819

Protein name: E3 ubiquitin-protein ligase RNF130 (EC 2.3.2.27) (Goliath homolog) (H-Goliath) (RING finger protein 130) (RING-type E3 ubiquitin transferase RNF130)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for RNF130 in