DegronMD

Uniprot ID: Q86XS8

Source protein: E3 ubiquitin-protein ligase RNF130

Source gene: RNF130

Class: DEG_APCC_DBOX_1

Location: 191:199

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6104

ASA_SCORE: 50.5889

COIL: 0.2117

CONS_SCORE: 0.4266

DSS_SCORE: 0.0128

HELIX: 0.7812

FCONS_SCORE: 1.033

RIG_SCORE: 0.9168

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G182V	TCGA-AP-A0LM	UCEC	TCGA	SRGSLVFVS	DEG_APCC_DBOX_1	0.0833
p.G182V	DO43306	UCEC	ICGC	SRGSLVFVS	DEG_APCC_DBOX_1	0.0833
p.P186S	TCGA-AX-A06F	UCEC	TCGA	SRGSLVFVS	DEG_APCC_DBOX_1	0.1944
p.P186S	TCGA-QK-A8Z7	HNSC	TCGA	SRGSLVFVS	DEG_APCC_DBOX_1	0.1944
p.P186S	DO52096	HNSC	ICGC	SRGSLVFVS	DEG_APCC_DBOX_1	0.1944
p.P186S	DO41752	UCEC	ICGC	SRGSLVFVS	DEG_APCC_DBOX_1	0.1944
p.S209Y	TCGA-BS-A0UF	UCEC	TCGA	SRGSLVFVS	DEG_APCC_DBOX_1	0.5
p.S209Y	DO41488	UCEC	ICGC	SRGSLVFVS	DEG_APCC_DBOX_1	0.5
p.M185K	TCGA-CN-6024	HNSC	TCGA	SRGSLVFVS	DEG_APCC_DBOX_1	0.1667
p.M185K	DO15326	HNSC	ICGC	SRGSLVFVS	DEG_APCC_DBOX_1	0.1667
p.P187L	DO222955	BTCA	ICGC	SRGSLVFVS	DEG_APCC_DBOX_1	0.2222
p.I208L	DO230313	COCA	ICGC	SRGSLVFVS	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XS8	E3 ubiquitin-protein ligase RNF130	DEG_APCC_DBOX_1	191:199	SRGSLVFVS	APC,CDC20,FZR1	0.6104	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons