DegronMD

Uniprot ID: Q9BR09

Source protein: Neuralized-like protein 2

Source gene: NEURL2

Class: DEG_APCC_DBOX_1

Location: 186:194

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8218

ASA_SCORE: 44.6222

COIL: 0.33

CONS_SCORE: 0.616

DSS_SCORE: 0.3062

HELIX: 0.0363

FCONS_SCORE: 1.4447

RIG_SCORE: 0.799

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D199E	TCGA-BR-4369	STAD	TCGA	RRSRLGVLF	DEG_APCC_DBOX_1	0.1944
p.D199E	DO38659	STAD	ICGC	RRSRLGVLF	DEG_APCC_DBOX_1	0.1944
p.D199N	TCGA-BR-6852	STAD	TCGA	RRSRLGVLF	DEG_APCC_DBOX_1	0.1944
p.D199N	DO38202	STAD	ICGC	RRSRLGVLF	DEG_APCC_DBOX_1	0.1944
p.D199Y	TCGA-MU-A8JM	CESC	TCGA	RRSRLGVLF	DEG_APCC_DBOX_1	0.1944
p.D199Y	DO49002	CESC	ICGC	RRSRLGVLF	DEG_APCC_DBOX_1	0.1944
p.G200D	DO233168	GACA	ICGC	RRSRLGVLF	DEG_APCC_DBOX_1	0.1667
p.P196R	SIDM00447	B-Lymphoblastic Leukemia	GDSC	RRSRLGVLF	DEG_APCC_DBOX_1	0.2778
p.P196R	ACH-000960	Leukemia	CCLE	RRSRLGVLF	DEG_APCC_DBOX_1	0.2778
p.P196R	REH	haematopoietic_and_lymphoid_tissue	COSMIC	RRSRLGVLF	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BR09	Neuralized-like protein 2	DEG_APCC_DBOX_1	186:194	RRSRLGVLF	APC,CDC20,FZR1	0.8218	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons