DegronMD

Uniprot ID: P10244

Source protein: Myb-related protein B

Source gene: MYBL2

Class: DEG_APCC_DBOX_1

Location: 416:424

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.999

ASA_SCORE: 103.4889

COIL: 0.8146

CONS_SCORE: 0.3731

DSS_SCORE: 0.4929

HELIX: 0.1262

FCONS_SCORE: 1.1742

RIG_SCORE: 0.7402

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R417C	TCGA-2W-A8YY	CESC	TCGA	RRVALSPVT	DEG_APCC_DBOX_1	0.8301
p.R417C	TCGA-XK-AAIW	PRAD	TCGA	RRVALSPVT	DEG_APCC_DBOX_1	0.8301
p.R417H	TCGA-34-5231	LUSC	TCGA	RRVALSPVT	DEG_APCC_DBOX_1	0.8244
p.D434Y	TCGA-64-5774	LUAD	TCGA	RRVALSPVT	DEG_APCC_DBOX_1	0.0556
p.A419S	TCGA-78-7536	LUAD	TCGA	RRVALSPVT	DEG_APCC_DBOX_1	0.6477
p.R412Q	TCGA-DF-A2KU	UCEC	TCGA	RRVALSPVT	DEG_APCC_DBOX_1	0.2222
p.P407L	TCGA-ER-A198	SKCM	TCGA	RRVALSPVT	DEG_APCC_DBOX_1	0.0833
p.P407L	SIDM01175	Other Sarcomas	GDSC	RRVALSPVT	DEG_APCC_DBOX_1	0.0833
p.P407L	ACH-002309	Sarcoma	CCLE	RRVALSPVT	DEG_APCC_DBOX_1	0.0833
p.P407L	SW684	soft_tissue	COSMIC	RRVALSPVT	DEG_APCC_DBOX_1	0.0833
p.R412W	TCGA-FI-A2D5	UCEC	TCGA	RRVALSPVT	DEG_APCC_DBOX_1	0.2222
p.E425K	TCGA-H2-A421	THCA	TCGA	RRVALSPVT	DEG_APCC_DBOX_1	0.3056
p.E425K	TCGA-T2-A6WZ	HNSC	TCGA	RRVALSPVT	DEG_APCC_DBOX_1	0.3056
p.S419N	DO48382	BLCA	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	0.7069
p.S430F	DO51893	BLCA	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	0.1667
p.V422L	DO44035	BLCA	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	0.6765
p.T416M	DO234237	ESAD	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	0.7423
p.P421A	DO22926	LIHC	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	0.7503
p.D410Y	DO24770	LUAD	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	0.1667
p.S411F	DO45482	LUSC	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	0.6389
p.S414I	DO37452	SKCM	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	0.2778
p.P426A	DO231326	THCA	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	0.2778
p.S428L	DO43899	UCEC	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	0.2222
p.P429S	DO43747	UCEC	ICGC	RRVALSPVT	DEG_APCC_DBOX_1	0.1944
p.A419G	SIDM01119	Other Solid Cancers	GDSC	RRVALSPVT	DEG_APCC_DBOX_1	0.6429
p.A419G	ACH-000775	Lung Cancer	CCLE	RRVALSPVT	DEG_APCC_DBOX_1	0.6429
p.A419G	NCI-H727	lung	COSMIC	RRVALSPVT	DEG_APCC_DBOX_1	0.6429
p.Q413R	ACH-001414	Bladder Cancer	CCLE	RRVALSPVT	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRVALSPVT

Degron related mutations and impact score

Drug responses associated with MYBL2 mutations

All proteins holding degron of RRVALSPVT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10244	Myb-related protein B	DEG_APCC_DBOX_1	416:424	RRVALSPVT	APC,CDC20,FZR1	0.999	More...