DegronMD

Uniprot ID: P33527

Source protein: Multidrug resistance-associated protein 1

Source gene: ABCC1

Class: LIG_APCC_ABBAyCdc20_2

Location: 194:200

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6162

ASA_SCORE: 77.1714

COIL: 0.806

CONS_SCORE: 0.2

DSS_SCORE: 0.1006

HELIX: 0.1469

FCONS_SCORE: 0.7452

RIG_SCORE: 0.7736

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S195L	TCGA-33-4547	LUSC	TCGA	RSPLFSE	LIG_APCC_ABBAyCdc20_2	0.6556
p.S195L	DO26546	LUSC	ICGC	RSPLFSE	LIG_APCC_ABBAyCdc20_2	0.6556
p.I184M	TCGA-F5-6814	READ	TCGA	RSPLFSE	LIG_APCC_ABBAyCdc20_2	0.0556
p.I184M	DO36556	READ	ICGC	RSPLFSE	LIG_APCC_ABBAyCdc20_2	0.0556
p.P207S	TCGA-FR-A7UA	SKCM	TCGA	RSPLFSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P207S	DO51253	SKCM	ICGC	RSPLFSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P207L	TCGA-FW-A3R5	SKCM	TCGA	RSPLFSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P207L	DO37406	SKCM	ICGC	RSPLFSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R194H	TCGA-QF-A5YS	UCEC	TCGA	RSPLFSE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R194H	DO52426	UCEC	ICGC	RSPLFSE	LIG_APCC_ABBAyCdc20_2	0.8244
p.Q185E	DO50725	ORCA	ICGC	RSPLFSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.V187I	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	RSPLFSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.V187I	ACH-000781	Lung Cancer	CCLE	RSPLFSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.V187I	NCI-H2023	lung	COSMIC	RSPLFSE	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P33527	Multidrug resistance-associated protein 1	LIG_APCC_ABBAyCdc20_2	194:200	RSPLFSE	APC,CDC20,FZR1	0.6162	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons