DegronMD - P33527(ABCC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F1295L	TCGA-2G-AAGC	TGCT	TCGA	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation rewiring degron network	0.1389
p.S195L	TCGA-33-4547	LUSC	TCGA	RSPLFSE	LIG_APCC_ABBAyCdc20_2	194:200	Mutation altering degron motif	0.6556
p.S195L	DO26546	LUSC	ICGC	RSPLFSE	LIG_APCC_ABBAyCdc20_2	194:200	Mutation altering degron motif	0.6556
p.G1320R	TCGA-A5-A0G2	UCEC	TCGA	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation rewiring degron network	0.0556
p.G1319V	TCGA-AA-3672	COAD	TCGA	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation rewiring degron network	0.0833
p.R1303Q	TCGA-AA-3819	COAD	TCGA	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation altering degron motif	0.7329
p.R1303Q	SIDM00400	B-Cell Non-Hodgkin's Lymphoma	GDSC	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation altering degron motif	0.7329
p.R1303Q	ACH-002392	Lymphoma	CCLE	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation altering degron motif	0.7329
p.I184M	TCGA-F5-6814	READ	TCGA	RSPLFSE	LIG_APCC_ABBAyCdc20_2	194:200	Mutation rewiring degron network	0.0556
p.I184M	DO36556	READ	ICGC	RSPLFSE	LIG_APCC_ABBAyCdc20_2	194:200	Mutation rewiring degron network	0.0556
p.P207S	TCGA-FR-A7UA	SKCM	TCGA	RSPLFSE	LIG_APCC_ABBAyCdc20_2	194:200	Mutation rewiring degron network	0.1389
p.P207S	DO51253	SKCM	ICGC	RSPLFSE	LIG_APCC_ABBAyCdc20_2	194:200	Mutation rewiring degron network	0.1389
p.P207L	TCGA-FW-A3R5	SKCM	TCGA	RSPLFSE	LIG_APCC_ABBAyCdc20_2	194:200	Mutation rewiring degron network	0.1389
p.P207L	DO37406	SKCM	ICGC	RSPLFSE	LIG_APCC_ABBAyCdc20_2	194:200	Mutation rewiring degron network	0.1389
p.R194H	TCGA-QF-A5YS	UCEC	TCGA	RSPLFSE	LIG_APCC_ABBAyCdc20_2	194:200	Mutation altering degron motif	0.8244
p.R194H	DO52426	UCEC	ICGC	RSPLFSE	LIG_APCC_ABBAyCdc20_2	194:200	Mutation altering degron motif	0.8244
p.G1303D	DO3686	BRCA	ICGC	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation altering degron motif	0.7198
p.V1319A	DO7783	COAD	ICGC	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation rewiring degron network	0.0833
p.L1320F	DO228952	LICA	ICGC	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation rewiring degron network	0.0556
p.D1306Y	DO228985	LICA	ICGC	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation altering degron motif	0.7325
p.P1315L	DO50970	LICA	ICGC	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation rewiring degron network	0.1944
p.R1308H	DO231538	LINC	ICGC	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation altering degron motif	0.8244
p.Q185E	DO50725	ORCA	ICGC	RSPLFSE	LIG_APCC_ABBAyCdc20_2	194:200	Mutation rewiring degron network	0.0833
p.P1315H	DO47407	SKCM	ICGC	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation rewiring degron network	0.1944
p.A1300T	DO41020	UCEC	ICGC	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation rewiring degron network	0.2778
p.I1302T	DO52402	UCEC	ICGC	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation altering degron motif	0.7078
p.T1316R	SIDM01090	Colorectal Carcinoma	GDSC	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation rewiring degron network	0.1667
p.T1316R	ACH-000943	Colon/Colorectal Cancer	CCLE	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation rewiring degron network	0.1667
p.T1316R	RKO	large intestine	COSMIC	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation rewiring degron network	0.1667
p.R1301H	SIDM00151	Ovarian Carcinoma	GDSC	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation rewiring degron network	0.3056
p.R1301H	ACH-000966	Ovarian Cancer	CCLE	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation rewiring degron network	0.3056
p.R1301H	IGROV-1	ovary	COSMIC	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation rewiring degron network	0.3056
p.V187I	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	RSPLFSE	LIG_APCC_ABBAyCdc20_2	194:200	Mutation rewiring degron network	0.1389
p.V187I	ACH-000781	Lung Cancer	CCLE	RSPLFSE	LIG_APCC_ABBAyCdc20_2	194:200	Mutation rewiring degron network	0.1389
p.V187I	NCI-H2023	lung	COSMIC	RSPLFSE	LIG_APCC_ABBAyCdc20_2	194:200	Mutation rewiring degron network	0.1389
p.N1318S	ACH-000901	Lung Cancer	CCLE	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation rewiring degron network	0.1111
p.T1316A	ACH-001038	Bone Cancer	CCLE	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation rewiring degron network	0.1667
p.T1316A	ACH-001794	Liposarcoma	CCLE	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation rewiring degron network	0.1667
p.T1316A	ACH-001795	Liposarcoma	CCLE	YREDLDFVL	DEG_APCC_DBOX_1	1302:1310	Mutation rewiring degron network	0.1667

Kaplan plot for ABCC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ABCC1

UniProt ID: P33527

Entrez ID: 4363

Protein name: Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ABCC1 in