DegronMD

Uniprot ID: P33527

Source protein: Multidrug resistance-associated protein 1

Source gene: ABCC1

Class: DEG_APCC_DBOX_1

Location: 1302:1310

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6656

ASA_SCORE: 66.3

COIL: 0.5714

CONS_SCORE: 0.67

DSS_SCORE: 0.0407

HELIX: 0.1736

FCONS_SCORE: 1.2245

RIG_SCORE: 0.9488

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1295L	TCGA-2G-AAGC	TGCT	TCGA	YREDLDFVL	DEG_APCC_DBOX_1	0.1389
p.G1320R	TCGA-A5-A0G2	UCEC	TCGA	YREDLDFVL	DEG_APCC_DBOX_1	0.0556
p.G1319V	TCGA-AA-3672	COAD	TCGA	YREDLDFVL	DEG_APCC_DBOX_1	0.0833
p.R1303Q	TCGA-AA-3819	COAD	TCGA	YREDLDFVL	DEG_APCC_DBOX_1	0.7329
p.R1303Q	SIDM00400	B-Cell Non-Hodgkin's Lymphoma	GDSC	YREDLDFVL	DEG_APCC_DBOX_1	0.7329
p.R1303Q	ACH-002392	Lymphoma	CCLE	YREDLDFVL	DEG_APCC_DBOX_1	0.7329
p.G1303D	DO3686	BRCA	ICGC	YREDLDFVL	DEG_APCC_DBOX_1	0.7198
p.V1319A	DO7783	COAD	ICGC	YREDLDFVL	DEG_APCC_DBOX_1	0.0833
p.L1320F	DO228952	LICA	ICGC	YREDLDFVL	DEG_APCC_DBOX_1	0.0556
p.D1306Y	DO228985	LICA	ICGC	YREDLDFVL	DEG_APCC_DBOX_1	0.7325
p.P1315L	DO50970	LICA	ICGC	YREDLDFVL	DEG_APCC_DBOX_1	0.1944
p.R1308H	DO231538	LINC	ICGC	YREDLDFVL	DEG_APCC_DBOX_1	0.8244
p.P1315H	DO47407	SKCM	ICGC	YREDLDFVL	DEG_APCC_DBOX_1	0.1944
p.A1300T	DO41020	UCEC	ICGC	YREDLDFVL	DEG_APCC_DBOX_1	0.2778
p.I1302T	DO52402	UCEC	ICGC	YREDLDFVL	DEG_APCC_DBOX_1	0.7078
p.T1316R	SIDM01090	Colorectal Carcinoma	GDSC	YREDLDFVL	DEG_APCC_DBOX_1	0.1667
p.T1316R	ACH-000943	Colon/Colorectal Cancer	CCLE	YREDLDFVL	DEG_APCC_DBOX_1	0.1667
p.T1316R	RKO	large_intestine	COSMIC	YREDLDFVL	DEG_APCC_DBOX_1	0.1667
p.R1301H	SIDM00151	Ovarian Carcinoma	GDSC	YREDLDFVL	DEG_APCC_DBOX_1	0.3056
p.R1301H	ACH-000966	Ovarian Cancer	CCLE	YREDLDFVL	DEG_APCC_DBOX_1	0.3056
p.R1301H	IGROV-1	ovary	COSMIC	YREDLDFVL	DEG_APCC_DBOX_1	0.3056
p.N1318S	ACH-000901	Lung Cancer	CCLE	YREDLDFVL	DEG_APCC_DBOX_1	0.1111
p.T1316A	ACH-001038	Bone Cancer	CCLE	YREDLDFVL	DEG_APCC_DBOX_1	0.1667
p.T1316A	ACH-001794	Liposarcoma	CCLE	YREDLDFVL	DEG_APCC_DBOX_1	0.1667
p.T1316A	ACH-001795	Liposarcoma	CCLE	YREDLDFVL	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P33527	Multidrug resistance-associated protein 1	DEG_APCC_DBOX_1	1302:1310	YREDLDFVL	APC,CDC20,FZR1	0.6656	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: YREDLDFVL

Degron related mutations and impact score

Drug responses associated with ABCC1 mutations

All proteins holding degron of YREDLDFVL