DegronMD

Uniprot ID: Q8TEY5

Source protein: Cyclic AMP-responsive element-binding protein 3-like protein 4

Source gene: CREB3L4

Class: LIG_APCC_ABBAyCdc20_2

Location: 387:393

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7036

ASA_SCORE: 88.3714

COIL: 0.6223

CONS_SCORE: 0.4646

DSS_SCORE: 0.8171

HELIX: 0.1879

FCONS_SCORE: 1.097

RIG_SCORE: 0.7393

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R387L	TCGA-AB-2885	LAML	TCGA	RSVLHAD	LIG_APCC_ABBAyCdc20_2	0.8428
p.R387L	DO21397	LAML	ICGC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	0.8428
p.R387L	DO229035	LICA	ICGC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	0.8428
p.S383R	DO228546	LICA	ICGC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	0.2222
p.A392T	DO35085	PACA	ICGC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	0.6028
p.R385C	DO232878	PEME	ICGC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R385C	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	0.2778
p.P380R	SIDM00353	Other Sarcomas	GDSC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	0.1389
p.P380R	ACH-000505	Sarcoma	CCLE	RSVLHAD	LIG_APCC_ABBAyCdc20_2	0.1389
p.P380R	RKN	ovary	COSMIC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	0.1389
p.G378R	SIDM00007	Other Solid Cancers	GDSC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	0.0833
p.G378R	ACH-001550	Skin Cancer	CCLE	RSVLHAD	LIG_APCC_ABBAyCdc20_2	0.0833
p.G378R	MCC13	skin	COSMIC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R385H	SIDM00487	Colorectal Carcinoma	GDSC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R385H	ACH-000963	Colon/Colorectal Cancer	CCLE	RSVLHAD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R385H	CCK-81	large_intestine	COSMIC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	0.2778
p.V389M	SIDM01121	Small Cell Lung Carcinoma	GDSC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	0.6097
p.G384E	ACH-000737	Lung Cancer	CCLE	RSVLHAD	LIG_APCC_ABBAyCdc20_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEY5	Cyclic AMP-responsive element-binding protein 3-like protein 4	LIG_APCC_ABBAyCdc20_2	387:393	RSVLHAD	APC,CDC20,FZR1	0.7036	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons