DegronMD - Q8TEY5(CREB3L4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M376T	TCGA-5M-AAT6	COAD	TCGA	TRTLLEKMG	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.7423
p.M376T	DO223703	COAD	ICGC	TRTLLEKMG	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.7423
p.R387L	TCGA-AB-2885	LAML	TCGA	RSVLHAD	LIG_APCC_ABBAyCdc20_2	387:393	Mutation altering degron motif	0.8428
p.R387L	DO21397	LAML	ICGC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	387:393	Mutation altering degron motif	0.8428
p.R387L	DO229035	LICA	ICGC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	387:393	Mutation altering degron motif	0.8428
p.T369A	TCGA-AX-A06F	UCEC	TCGA	TRTLLEKMG	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.7139
p.T369A	DO41752	UCEC	ICGC	TRTLLEKMG	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.7139
p.S383R	DO228546	LICA	ICGC	TRTLLEKMG	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.1667
p.S383R	DO228546	LICA	ICGC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	387:393	Mutation rewiring degron network	0.2222
p.G361E	DO229056	LICA	ICGC	TRTLLEKMG	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.1111
p.A392T	DO35085	PACA	ICGC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	387:393	Mutation altering degron motif	0.6028
p.K375T	DO49451	PACA	ICGC	TRTLLEKMG	DEG_APCC_DBOX_1	369:377	Mutation altering degron motif	0.6195
p.R385C	DO232878	PEME	ICGC	TRTLLEKMG	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.1111
p.R385C	DO232878	PEME	ICGC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	387:393	Mutation rewiring degron network	0.2778
p.R385C	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	TRTLLEKMG	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.1111
p.R385C	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	387:393	Mutation rewiring degron network	0.2778
p.P380R	SIDM00353	Other Sarcomas	GDSC	TRTLLEKMG	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.25
p.P380R	SIDM00353	Other Sarcomas	GDSC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	387:393	Mutation rewiring degron network	0.1389
p.P380R	ACH-000505	Sarcoma	CCLE	TRTLLEKMG	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.25
p.P380R	ACH-000505	Sarcoma	CCLE	RSVLHAD	LIG_APCC_ABBAyCdc20_2	387:393	Mutation rewiring degron network	0.1389
p.P380R	RKN	ovary	COSMIC	TRTLLEKMG	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.25
p.P380R	RKN	ovary	COSMIC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	387:393	Mutation rewiring degron network	0.1389
p.G378R	SIDM00007	Other Solid Cancers	GDSC	TRTLLEKMG	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.3056
p.G378R	SIDM00007	Other Solid Cancers	GDSC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	387:393	Mutation rewiring degron network	0.0833
p.G378R	ACH-001550	Skin Cancer	CCLE	TRTLLEKMG	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.3056
p.G378R	ACH-001550	Skin Cancer	CCLE	RSVLHAD	LIG_APCC_ABBAyCdc20_2	387:393	Mutation rewiring degron network	0.0833
p.G378R	MCC13	skin	COSMIC	TRTLLEKMG	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.3056
p.G378R	MCC13	skin	COSMIC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	387:393	Mutation rewiring degron network	0.0833
p.R385H	SIDM00487	Colorectal Carcinoma	GDSC	TRTLLEKMG	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.1111
p.R385H	SIDM00487	Colorectal Carcinoma	GDSC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	387:393	Mutation rewiring degron network	0.2778
p.R385H	ACH-000963	Colon/Colorectal Cancer	CCLE	TRTLLEKMG	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.1111
p.R385H	ACH-000963	Colon/Colorectal Cancer	CCLE	RSVLHAD	LIG_APCC_ABBAyCdc20_2	387:393	Mutation rewiring degron network	0.2778
p.R385H	CCK-81	large intestine	COSMIC	TRTLLEKMG	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.1111
p.R385H	CCK-81	large intestine	COSMIC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	387:393	Mutation rewiring degron network	0.2778
p.V389M	SIDM01121	Small Cell Lung Carcinoma	GDSC	RSVLHAD	LIG_APCC_ABBAyCdc20_2	387:393	Mutation altering degron motif	0.6097
p.G384E	ACH-000737	Lung Cancer	CCLE	TRTLLEKMG	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.1389
p.G384E	ACH-000737	Lung Cancer	CCLE	RSVLHAD	LIG_APCC_ABBAyCdc20_2	387:393	Mutation rewiring degron network	0.25
p.R365H	CCK-81	large intestine	COSMIC	TRTLLEKMG	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.2222
p.P360R	RKN	ovary	COSMIC	TRTLLEKMG	DEG_APCC_DBOX_1	369:377	Mutation rewiring degron network	0.0833

Kaplan plot for CREB3L4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CREB3L4

UniProt ID: Q8TEY5

Entrez ID: 148327

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CREB3L4 in