DegronMD

Uniprot ID: Q8TEY5

Source protein: Cyclic AMP-responsive element-binding protein 3-like protein 4

Source gene: CREB3L4

Class: DEG_APCC_DBOX_1

Location: 369:377

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9122

ASA_SCORE: 75.9778

COIL: 0.4064

CONS_SCORE: 0.4323

DSS_SCORE: 0.7132

HELIX: 0.5464

FCONS_SCORE: 1.0116

RIG_SCORE: 0.7053

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M376T	TCGA-5M-AAT6	COAD	TCGA	TRTLLEKMG	DEG_APCC_DBOX_1	0.7423
p.M376T	DO223703	COAD	ICGC	TRTLLEKMG	DEG_APCC_DBOX_1	0.7423
p.T369A	TCGA-AX-A06F	UCEC	TCGA	TRTLLEKMG	DEG_APCC_DBOX_1	0.7139
p.T369A	DO41752	UCEC	ICGC	TRTLLEKMG	DEG_APCC_DBOX_1	0.7139
p.S383R	DO228546	LICA	ICGC	TRTLLEKMG	DEG_APCC_DBOX_1	0.1667
p.G361E	DO229056	LICA	ICGC	TRTLLEKMG	DEG_APCC_DBOX_1	0.1111
p.K375T	DO49451	PACA	ICGC	TRTLLEKMG	DEG_APCC_DBOX_1	0.6195
p.R385C	DO232878	PEME	ICGC	TRTLLEKMG	DEG_APCC_DBOX_1	0.1111
p.R385C	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	TRTLLEKMG	DEG_APCC_DBOX_1	0.1111
p.P380R	SIDM00353	Other Sarcomas	GDSC	TRTLLEKMG	DEG_APCC_DBOX_1	0.25
p.P380R	ACH-000505	Sarcoma	CCLE	TRTLLEKMG	DEG_APCC_DBOX_1	0.25
p.P380R	RKN	ovary	COSMIC	TRTLLEKMG	DEG_APCC_DBOX_1	0.25
p.G378R	SIDM00007	Other Solid Cancers	GDSC	TRTLLEKMG	DEG_APCC_DBOX_1	0.3056
p.G378R	ACH-001550	Skin Cancer	CCLE	TRTLLEKMG	DEG_APCC_DBOX_1	0.3056
p.G378R	MCC13	skin	COSMIC	TRTLLEKMG	DEG_APCC_DBOX_1	0.3056
p.R385H	SIDM00487	Colorectal Carcinoma	GDSC	TRTLLEKMG	DEG_APCC_DBOX_1	0.1111
p.R385H	ACH-000963	Colon/Colorectal Cancer	CCLE	TRTLLEKMG	DEG_APCC_DBOX_1	0.1111
p.R385H	CCK-81	large_intestine	COSMIC	TRTLLEKMG	DEG_APCC_DBOX_1	0.1111
p.G384E	ACH-000737	Lung Cancer	CCLE	TRTLLEKMG	DEG_APCC_DBOX_1	0.1389
p.R365H	CCK-81	large_intestine	COSMIC	TRTLLEKMG	DEG_APCC_DBOX_1	0.2222
p.P360R	RKN	ovary	COSMIC	TRTLLEKMG	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEY5	Cyclic AMP-responsive element-binding protein 3-like protein 4	DEG_APCC_DBOX_1	369:377	TRTLLEKMG	APC,CDC20,FZR1	0.9122	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons