DegronMD

Uniprot ID: A8MQ27

Source protein: E3 ubiquitin-protein ligase NEURL1B

Source gene: NEURL1B

Class: LIG_APCC_ABBAyCdc20_2

Location: 308:314

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6658

ASA_SCORE: 36.6429

COIL: 0.3527

CONS_SCORE: 0.5439

DSS_SCORE: 0.5122

HELIX: 0.0184

FCONS_SCORE: 1.387

RIG_SCORE: 0.7754

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P313L	DO223732	CESC	ICGC	RTLVFSE	LIG_APCC_ABBAyCdc20_2	0.7582
p.C321R	DO233693	GACA	ICGC	RTLVFSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.T322M	DO233792	GACA	ICGC	RTLVFSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.T322M	DO229540	UTCA	ICGC	RTLVFSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.S309F	DO222572	MELA	ICGC	RTLVFSE	LIG_APCC_ABBAyCdc20_2	0.7982
p.F308Y	DO222775	MELA	ICGC	RTLVFSE	LIG_APCC_ABBAyCdc20_2	0.7528
p.V304M	DO46593	OV	ICGC	RTLVFSE	LIG_APCC_ABBAyCdc20_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MQ27	E3 ubiquitin-protein ligase NEURL1B	LIG_APCC_ABBAyCdc20_2	308:314	RTLVFSE	APC,CDC20,FZR1	0.6658	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons