DegronMD - A8MQ27(NEURL1B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P87T	DO228352	BRCA	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.7031
p.A88V	DO229378	BTCA	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.5825
p.A88V	DO219106	COAD	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.5825
p.A88V	ACH-001369	Ovarian Cancer	CCLE	VRLRLVAVR	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.5825
p.P313L	DO223732	CESC	ICGC	RTLVFSE	LIG_APCC_ABBAyCdc20_2	308:314	Mutation altering degron motif	0.7582
p.A74T	DO227976	COCA	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1111
p.L86P	DO50319	ESAD	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.7582
p.A73T	DO234361	ESAD	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.0833
p.C321R	DO233693	GACA	ICGC	RTLVFSE	LIG_APCC_ABBAyCdc20_2	308:314	Mutation rewiring degron network	0.1389
p.T322M	DO233792	GACA	ICGC	RTLVFSE	LIG_APCC_ABBAyCdc20_2	308:314	Mutation rewiring degron network	0.1111
p.T322M	DO229540	UTCA	ICGC	RTLVFSE	LIG_APCC_ABBAyCdc20_2	308:314	Mutation rewiring degron network	0.1111
p.P75S	DO233898	GACA	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1389
p.R74W	DO233903	GACA	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1111
p.P75L	DO220907	MELA	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1389
p.S309F	DO222572	MELA	ICGC	RTLVFSE	LIG_APCC_ABBAyCdc20_2	308:314	Mutation altering degron motif	0.7982
p.F308Y	DO222775	MELA	ICGC	RTLVFSE	LIG_APCC_ABBAyCdc20_2	308:314	Mutation altering degron motif	0.7528
p.V304M	DO46593	OV	ICGC	RTLVFSE	LIG_APCC_ABBAyCdc20_2	308:314	Mutation rewiring degron network	0.2222
p.R74Q	DO35442	PACA	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1111
p.A96V	DO52151	PAEN	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1667
p.R90C	DO229211	THCA	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.719
p.T72M	DO229229	THCA	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.0556
p.E80K	ACH-000338	Lymphoma	CCLE	VRLRLVAVR	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.2778
p.V82A	ACH-000982	Colon/Colorectal Cancer	CCLE	VRLRLVAVR	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.5825
p.V82A	ACH-001345	Colon/Colorectal Cancer	CCLE	VRLRLVAVR	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.5825
p.A417V	ACH-000982	Colon/Colorectal Cancer	CCLE	PRGRLLCVD	DEG_APCC_DBOX_1	402:410	Mutation rewiring degron network	0.1389

Kaplan plot for NEURL1B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NEURL1B

UniProt ID: A8MQ27

Entrez ID: 54492

Protein name: E3 ubiquitin-protein ligase NEURL1B (EC 2.3.2.27) (Neuralized-2) (NEUR2) (Neuralized-like protein 1B) (Neuralized-like protein 3) (RING-type E3 ubiquitin transferase NEURL1B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NEURL1B in