DegronMD

Uniprot ID: A8MQ27

Source protein: E3 ubiquitin-protein ligase NEURL1B

Source gene: NEURL1B

Class: DEG_APCC_DBOX_1

Location: 82:90

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7921

ASA_SCORE: 55.0111

COIL: 0.1468

CONS_SCORE: 0.3878

DSS_SCORE: 0.0803

HELIX: 0.0083

FCONS_SCORE: 0.7635

RIG_SCORE: 0.9147

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P87T	DO228352	BRCA	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	0.7031
p.A88V	DO229378	BTCA	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	0.5825
p.A88V	DO219106	COAD	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	0.5825
p.A88V	ACH-001369	Ovarian Cancer	CCLE	VRLRLVAVR	DEG_APCC_DBOX_1	0.5825
p.A74T	DO227976	COCA	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	0.1111
p.L86P	DO50319	ESAD	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	0.7582
p.A73T	DO234361	ESAD	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	0.0833
p.P75S	DO233898	GACA	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	0.1389
p.R74W	DO233903	GACA	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	0.1111
p.P75L	DO220907	MELA	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	0.1389
p.R74Q	DO35442	PACA	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	0.1111
p.A96V	DO52151	PAEN	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	0.1667
p.R90C	DO229211	THCA	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	0.719
p.T72M	DO229229	THCA	ICGC	VRLRLVAVR	DEG_APCC_DBOX_1	0.0556
p.E80K	ACH-000338	Lymphoma	CCLE	VRLRLVAVR	DEG_APCC_DBOX_1	0.2778
p.V82A	ACH-000982	Colon/Colorectal Cancer	CCLE	VRLRLVAVR	DEG_APCC_DBOX_1	0.5825
p.V82A	ACH-001345	Colon/Colorectal Cancer	CCLE	VRLRLVAVR	DEG_APCC_DBOX_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MQ27	E3 ubiquitin-protein ligase NEURL1B	DEG_APCC_DBOX_1	82:90	VRLRLVAVR	APC,CDC20,FZR1	0.7921	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons