DegronMD

Uniprot ID: Q6S5L8

Source protein: SHC-transforming protein 4

Source gene: SHC4

Class: LIG_APCC_ABBAyCdc20_2

Location: 456:462

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5613

ASA_SCORE: 70.7571

COIL: 0.7709

CONS_SCORE: 0.4263

DSS_SCORE: 0.2003

HELIX: 0.1399

FCONS_SCORE: 1.0289

RIG_SCORE: 0.8669

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N467S	TCGA-4P-AA8J	HNSC	TCGA	RVDLFDD	LIG_APCC_ABBAyCdc20_2	0.1944
p.R456Q	TCGA-AA-3510	COAD	TCGA	RVDLFDD	LIG_APCC_ABBAyCdc20_2	0.7329
p.R456Q	TCGA-B5-A3FA	UCEC	TCGA	RVDLFDD	LIG_APCC_ABBAyCdc20_2	0.7329
p.R456Q	SIDM00120	Prostate Carcinoma	GDSC	RVDLFDD	LIG_APCC_ABBAyCdc20_2	0.7329
p.R456Q	ACH-000979	Prostate Cancer	CCLE	RVDLFDD	LIG_APCC_ABBAyCdc20_2	0.7329
p.R456Q	DU-145	prostate	COSMIC	RVDLFDD	LIG_APCC_ABBAyCdc20_2	0.7329
p.L451S	TCGA-B5-A1MX	UCEC	TCGA	RVDLFDD	LIG_APCC_ABBAyCdc20_2	0.1944
p.V457A	SIDM00216	Colorectal Carcinoma	GDSC	RVDLFDD	LIG_APCC_ABBAyCdc20_2	0.5825
p.V457A	ACH-000989	Colon/Colorectal Cancer	CCLE	RVDLFDD	LIG_APCC_ABBAyCdc20_2	0.5825
p.V457A	SNU-175	large_intestine	COSMIC	RVDLFDD	LIG_APCC_ABBAyCdc20_2	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6S5L8	SHC-transforming protein 4	LIG_APCC_ABBAyCdc20_2	456:462	RVDLFDD	APC,CDC20,FZR1	0.5613	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons