DegronMD - Q6S5L8(SHC4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N467S	TCGA-4P-AA8J	HNSC	TCGA	VDLFDD	LIG_APCC_ABBA_1	457:462	Mutation rewiring degron network	0.1944
p.N467S	TCGA-4P-AA8J	HNSC	TCGA	RVDLFDD	LIG_APCC_ABBAyCdc20_2	456:462	Mutation rewiring degron network	0.1944
p.R456Q	TCGA-AA-3510	COAD	TCGA	RVDLFDD	LIG_APCC_ABBAyCdc20_2	456:462	Mutation altering degron motif	0.7329
p.R456Q	TCGA-B5-A3FA	UCEC	TCGA	RVDLFDD	LIG_APCC_ABBAyCdc20_2	456:462	Mutation altering degron motif	0.7329
p.R456Q	SIDM00120	Prostate Carcinoma	GDSC	RVDLFDD	LIG_APCC_ABBAyCdc20_2	456:462	Mutation altering degron motif	0.7329
p.R456Q	ACH-000979	Prostate Cancer	CCLE	RVDLFDD	LIG_APCC_ABBAyCdc20_2	456:462	Mutation altering degron motif	0.7329
p.R456Q	DU-145	prostate	COSMIC	RVDLFDD	LIG_APCC_ABBAyCdc20_2	456:462	Mutation altering degron motif	0.7329
p.L451S	TCGA-B5-A1MX	UCEC	TCGA	VDLFDD	LIG_APCC_ABBA_1	457:462	Mutation rewiring degron network	0.1667
p.L451S	TCGA-B5-A1MX	UCEC	TCGA	RVDLFDD	LIG_APCC_ABBAyCdc20_2	456:462	Mutation rewiring degron network	0.1944
p.V457A	SIDM00216	Colorectal Carcinoma	GDSC	VDLFDD	LIG_APCC_ABBA_1	457:462	Mutation altering degron motif	0.6936
p.V457A	SIDM00216	Colorectal Carcinoma	GDSC	RVDLFDD	LIG_APCC_ABBAyCdc20_2	456:462	Mutation altering degron motif	0.5825
p.V457A	ACH-000989	Colon/Colorectal Cancer	CCLE	VDLFDD	LIG_APCC_ABBA_1	457:462	Mutation altering degron motif	0.6936
p.V457A	ACH-000989	Colon/Colorectal Cancer	CCLE	RVDLFDD	LIG_APCC_ABBAyCdc20_2	456:462	Mutation altering degron motif	0.5825
p.V457A	SNU-175	large intestine	COSMIC	VDLFDD	LIG_APCC_ABBA_1	457:462	Mutation altering degron motif	0.6936
p.V457A	SNU-175	large intestine	COSMIC	RVDLFDD	LIG_APCC_ABBAyCdc20_2	456:462	Mutation altering degron motif	0.5825

Kaplan plot for SHC4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SHC4

UniProt ID: Q6S5L8

Entrez ID: 399694

Protein name: SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SHC4 in