DegronMD

Uniprot ID: Q6S5L8

Source protein: SHC-transforming protein 4

Source gene: SHC4

Class: LIG_APCC_ABBA_1

Location: 457:462

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5626

ASA_SCORE: 65.4833

COIL: 0.7787

CONS_SCORE: 0.4238

DSS_SCORE: 0.2011

HELIX: 0.1402

FCONS_SCORE: 1.0115

RIG_SCORE: 0.8662

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N467S	TCGA-4P-AA8J	HNSC	TCGA	VDLFDD	LIG_APCC_ABBA_1	0.1944
p.L451S	TCGA-B5-A1MX	UCEC	TCGA	VDLFDD	LIG_APCC_ABBA_1	0.1667
p.V457A	SIDM00216	Colorectal Carcinoma	GDSC	VDLFDD	LIG_APCC_ABBA_1	0.6936
p.V457A	ACH-000989	Colon/Colorectal Cancer	CCLE	VDLFDD	LIG_APCC_ABBA_1	0.6936
p.V457A	SNU-175	large_intestine	COSMIC	VDLFDD	LIG_APCC_ABBA_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6S5L8	SHC-transforming protein 4	LIG_APCC_ABBA_1	457:462	VDLFDD	APC,CDC20,FZR1	0.5626	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons