DegronMD

Uniprot ID: Q7KYR7

Source protein: Butyrophilin subfamily 2 member A1

Source gene: BTN2A1

Class: LIG_APCC_ABBAyCdc20_2

Location: 449:455

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5402

ASA_SCORE: 18.8857

COIL: 0.037

CONS_SCORE: 0.7016

DSS_SCORE: 0.0547

HELIX: 0.0024

FCONS_SCORE: 1.2793

RIG_SCORE: 0.8973

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E445Q	TCGA-26-1799	GBM	TCGA	RVGVFLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E457K	TCGA-44-2668	LUAD	TCGA	RVGVFLD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E457K	SIDM00241	Breast Carcinoma	GDSC	RVGVFLD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E457K	ACH-002179	Breast Cancer	CCLE	RVGVFLD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E457K	OCUB-M	breast	COSMIC	RVGVFLD	LIG_APCC_ABBAyCdc20_2	0.2778
p.D460N	TCGA-63-5128	LUSC	TCGA	RVGVFLD	LIG_APCC_ABBAyCdc20_2	0.1944
p.P442H	TCGA-AJ-A3BG	UCEC	TCGA	RVGVFLD	LIG_APCC_ABBAyCdc20_2	0.1389
p.V452I	TCGA-BH-A0HA	BRCA	TCGA	RVGVFLD	LIG_APCC_ABBAyCdc20_2	0.5965
p.L454Q	TCGA-CC-A7IJ	LIHC	TCGA	RVGVFLD	LIG_APCC_ABBAyCdc20_2	0.6654
p.C448Y	TCGA-EE-A29M	SKCM	TCGA	RVGVFLD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G447W	DO47658	SKCM	ICGC	RVGVFLD	LIG_APCC_ABBAyCdc20_2	0.2778
p.A445G	DO47552	SKCM	ICGC	RVGVFLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.T449M	DO38795	STAD	ICGC	RVGVFLD	LIG_APCC_ABBAyCdc20_2	0.7423
p.P440L	DO41644	UCEC	ICGC	RVGVFLD	LIG_APCC_ABBAyCdc20_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7KYR7	Butyrophilin subfamily 2 member A1	LIG_APCC_ABBAyCdc20_2	449:455	RVGVFLD	APC,CDC20,FZR1	0.5402	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons