DegronMD - Q7KYR7(BTN2A1)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E445Q	TCGA-26-1799	GBM	TCGA	VGVFLD	LIG_APCC_ABBA_1	450:455	Mutation rewiring degron network	0.1944
p.E445Q	TCGA-26-1799	GBM	TCGA	RVGVFLD	LIG_APCC_ABBAyCdc20_2	449:455	Mutation rewiring degron network	0.2222
p.E457K	TCGA-44-2668	LUAD	TCGA	VGVFLD	LIG_APCC_ABBA_1	450:455	Mutation rewiring degron network	0.2778
p.E457K	TCGA-44-2668	LUAD	TCGA	RVGVFLD	LIG_APCC_ABBAyCdc20_2	449:455	Mutation rewiring degron network	0.2778
p.E457K	SIDM00241	Breast Carcinoma	GDSC	VGVFLD	LIG_APCC_ABBA_1	450:455	Mutation rewiring degron network	0.2778
p.E457K	SIDM00241	Breast Carcinoma	GDSC	RVGVFLD	LIG_APCC_ABBAyCdc20_2	449:455	Mutation rewiring degron network	0.2778
p.E457K	ACH-002179	Breast Cancer	CCLE	VGVFLD	LIG_APCC_ABBA_1	450:455	Mutation rewiring degron network	0.2778
p.E457K	ACH-002179	Breast Cancer	CCLE	RVGVFLD	LIG_APCC_ABBAyCdc20_2	449:455	Mutation rewiring degron network	0.2778
p.E457K	OCUB-M	breast	COSMIC	VGVFLD	LIG_APCC_ABBA_1	450:455	Mutation rewiring degron network	0.2778
p.E457K	OCUB-M	breast	COSMIC	RVGVFLD	LIG_APCC_ABBAyCdc20_2	449:455	Mutation rewiring degron network	0.2778
p.D460N	TCGA-63-5128	LUSC	TCGA	VGVFLD	LIG_APCC_ABBA_1	450:455	Mutation rewiring degron network	0.1944
p.D460N	TCGA-63-5128	LUSC	TCGA	RVGVFLD	LIG_APCC_ABBAyCdc20_2	449:455	Mutation rewiring degron network	0.1944
p.P442H	TCGA-AJ-A3BG	UCEC	TCGA	VGVFLD	LIG_APCC_ABBA_1	450:455	Mutation rewiring degron network	0.1111
p.P442H	TCGA-AJ-A3BG	UCEC	TCGA	RVGVFLD	LIG_APCC_ABBAyCdc20_2	449:455	Mutation rewiring degron network	0.1389
p.V452I	TCGA-BH-A0HA	BRCA	TCGA	VGVFLD	LIG_APCC_ABBA_1	450:455	Mutation altering degron motif	0.5965
p.V452I	TCGA-BH-A0HA	BRCA	TCGA	RVGVFLD	LIG_APCC_ABBAyCdc20_2	449:455	Mutation altering degron motif	0.5965
p.L454Q	TCGA-CC-A7IJ	LIHC	TCGA	VGVFLD	LIG_APCC_ABBA_1	450:455	Mutation altering degron motif	0.6654
p.L454Q	TCGA-CC-A7IJ	LIHC	TCGA	RVGVFLD	LIG_APCC_ABBAyCdc20_2	449:455	Mutation altering degron motif	0.6654
p.C448Y	TCGA-EE-A29M	SKCM	TCGA	VGVFLD	LIG_APCC_ABBA_1	450:455	Mutation rewiring degron network	0.2778
p.C448Y	TCGA-EE-A29M	SKCM	TCGA	RVGVFLD	LIG_APCC_ABBAyCdc20_2	449:455	Mutation rewiring degron network	0.3056
p.G447W	DO47658	SKCM	ICGC	VGVFLD	LIG_APCC_ABBA_1	450:455	Mutation rewiring degron network	0.25
p.G447W	DO47658	SKCM	ICGC	RVGVFLD	LIG_APCC_ABBAyCdc20_2	449:455	Mutation rewiring degron network	0.2778
p.A445G	DO47552	SKCM	ICGC	VGVFLD	LIG_APCC_ABBA_1	450:455	Mutation rewiring degron network	0.1944
p.A445G	DO47552	SKCM	ICGC	RVGVFLD	LIG_APCC_ABBAyCdc20_2	449:455	Mutation rewiring degron network	0.2222
p.T449M	DO38795	STAD	ICGC	RVGVFLD	LIG_APCC_ABBAyCdc20_2	449:455	Mutation altering degron motif	0.7423
p.P440L	DO41644	UCEC	ICGC	VGVFLD	LIG_APCC_ABBA_1	450:455	Mutation rewiring degron network	0.0556
p.P440L	DO41644	UCEC	ICGC	RVGVFLD	LIG_APCC_ABBAyCdc20_2	449:455	Mutation rewiring degron network	0.0833

Kaplan plot for BTN2A1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BTN2A1

UniProt ID: Q7KYR7

Entrez ID: 11120

Protein name: Butyrophilin subfamily 2 member A1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BTN2A1 in