DegronMD

Uniprot ID: Q7KYR7

Source protein: Butyrophilin subfamily 2 member A1

Source gene: BTN2A1

Class: LIG_APCC_ABBA_1

Location: 450:455

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6048

ASA_SCORE: 10.5333

COIL: 0.0305

CONS_SCORE: 0.7059

DSS_SCORE: 0.0559

HELIX: 0.002

FCONS_SCORE: 1.2506

RIG_SCORE: 0.8986

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E445Q	TCGA-26-1799	GBM	TCGA	VGVFLD	LIG_APCC_ABBA_1	0.1944
p.E457K	TCGA-44-2668	LUAD	TCGA	VGVFLD	LIG_APCC_ABBA_1	0.2778
p.E457K	SIDM00241	Breast Carcinoma	GDSC	VGVFLD	LIG_APCC_ABBA_1	0.2778
p.E457K	ACH-002179	Breast Cancer	CCLE	VGVFLD	LIG_APCC_ABBA_1	0.2778
p.E457K	OCUB-M	breast	COSMIC	VGVFLD	LIG_APCC_ABBA_1	0.2778
p.D460N	TCGA-63-5128	LUSC	TCGA	VGVFLD	LIG_APCC_ABBA_1	0.1944
p.P442H	TCGA-AJ-A3BG	UCEC	TCGA	VGVFLD	LIG_APCC_ABBA_1	0.1111
p.V452I	TCGA-BH-A0HA	BRCA	TCGA	VGVFLD	LIG_APCC_ABBA_1	0.5965
p.L454Q	TCGA-CC-A7IJ	LIHC	TCGA	VGVFLD	LIG_APCC_ABBA_1	0.6654
p.C448Y	TCGA-EE-A29M	SKCM	TCGA	VGVFLD	LIG_APCC_ABBA_1	0.2778
p.G447W	DO47658	SKCM	ICGC	VGVFLD	LIG_APCC_ABBA_1	0.25
p.A445G	DO47552	SKCM	ICGC	VGVFLD	LIG_APCC_ABBA_1	0.1944
p.P440L	DO41644	UCEC	ICGC	VGVFLD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7KYR7	Butyrophilin subfamily 2 member A1	LIG_APCC_ABBA_1	450:455	VGVFLD	APC,CDC20,FZR1	0.6048	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons