DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
RVLLYHE
Uniprot ID:
Q2TAK8
Source protein:
PWWP domain-containing DNA repair factor 3A
Source gene:
PWWP3A
Class:
LIG_APCC_ABBAyCdc20_2
Location:
399:405
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7797
ASA_SCORE:
95.6143
COIL:
0.7926
CONS_SCORE:
0.6261
DSS_SCORE:
0.4003
HELIX:
0.1476
FCONS_SCORE:
0.8758
RIG_SCORE:
0.7875
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PWWP3A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RVLLYHE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q2TAK8
PWWP domain-containing DNA repair factor 3A
LIG_APCC_ABBAyCdc20_2
399:405
RVLLYHE
APC,CDC20,FZR1
0.7797
More...