DegronMD: protein-targeted degradation, mutation and drug response to degrons
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CGC
Degron:
RVPVFED
Uniprot ID:
O76041
Source protein:
Nebulette
Source gene:
NEBL
Class:
LIG_APCC_ABBAyCdc20_2
Location:
2:8
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7412
ASA_SCORE:
93.1714
COIL:
0.5444
CONS_SCORE:
0.4036
DSS_SCORE:
0.8021
HELIX:
0.4187
FCONS_SCORE:
1.0199
RIG_SCORE:
0.7919
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D8Y
TCGA-55-A490
LUAD
TCGA
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.7325
p.D8Y
DO229060
LICA
ICGC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.7325
p.D8Y
DO24596
LUAD
ICGC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.7325
p.I18M
TCGA-AN-A0AM
BRCA
TCGA
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.0556
p.I18M
DO4191
BRCA
ICGC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.0556
p.D11Y
TCGA-BS-A0UF
UCEC
TCGA
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.25
p.D11Y
DO8264
COAD
ICGC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.25
p.D11Y
DO41488
UCEC
ICGC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.25
p.E14K
TCGA-C8-A1HM
BRCA
TCGA
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.1667
p.E14K
DO3904
BRCA
ICGC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.1667
p.E14G
TCGA-EO-A22X
UCEC
TCGA
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.1667
p.E14G
DO43907
UCEC
ICGC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.1667
p.E15K
TCGA-FW-A3R5
SKCM
TCGA
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.1389
p.E15K
DO37406
SKCM
ICGC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.1389
p.A6S
DO225004
BRCA
ICGC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.7588
p.E16K
DO230326
COCA
ICGC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.1111
p.Q4K
DO229027
LICA
ICGC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.6944
p.F4L
DO26469
LUSC
ICGC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.6981
p.E12K
DO222546
MELA
ICGC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.2222
p.E12K
DO222653
MELA
ICGC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.2222
p.E12D
DO46368
OV
ICGC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.2222
p.V18I
DO218861
SKCA
ICGC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.0556
p.K10N
DO41758
UCEC
ICGC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.2778
p.P4L
SIDM00454
Rhabdomyosarcoma
GDSC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.6471
p.P4L
SIDM00633
Breast Carcinoma
GDSC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.6471
p.P4L
SIDM01677
Non-Small Cell Lung Carcinoma
GDSC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.6471
p.D8N
SIDM00003
Melanoma
GDSC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.6932
p.D8N
SIDM00312
Plasma Cell Myeloma
GDSC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.6932
p.D8N
ACH-000183
Myeloma
CCLE
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.6932
p.D8N
ACH-002159
Skin Cancer
CCLE
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.6932
p.D8N
L-363
haematopoietic_and_lymphoid_tissue
COSMIC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.6932
p.D8N
M14
skin
COSMIC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.6932
p.V5A
SIDM00254
Neuroblastoma
GDSC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.6936
p.V5A
ACH-002283
Neuroblastoma
CCLE
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.6936
p.V5A
NB5
autonomic_ganglia
COSMIC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.6936
p.C5R
ACH-000971
Colon/Colorectal Cancer
CCLE
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.8301
p.C5R
HCT-116
large_intestine
COSMIC
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.8301
p.P14S
ACH-001119
Lymphoma
CCLE
RVPVFED
LIG_APCC_ABBAyCdc20_2
0.1667
Drug responses associated with NEBL mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RVPVFED
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O76041
Nebulette
LIG_APCC_ABBAyCdc20_2
2:8
RVPVFED
APC,CDC20,FZR1
0.7412
More...