DegronMD

Uniprot ID: O95992

Source protein: Cholesterol 25-hydroxylase

Source gene: CH25H

Class: LIG_APCC_ABBAyCdc20_2

Location: 70:76

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7352

ASA_SCORE: 80.3143

COIL: 0.779

CONS_SCORE: 0.64

DSS_SCORE: 0.0522

HELIX: 0.1504

FCONS_SCORE: 1.4817

RIG_SCORE: 0.8587

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A81T	TCGA-CK-5913	COAD	TCGA	RYKIHPD	LIG_APCC_ABBAyCdc20_2	0.1944
p.A81T	DO8826	COAD	ICGC	RYKIHPD	LIG_APCC_ABBAyCdc20_2	0.1944
p.S78L	TCGA-YC-A89H	BLCA	TCGA	RYKIHPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.S78L	DO51948	BLCA	ICGC	RYKIHPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.W64C	DO228935	COCA	ICGC	RYKIHPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.H74N	DO229008	LICA	ICGC	RYKIHPD	LIG_APCC_ABBAyCdc20_2	0.7423
p.P86L	SIDM01006	Plasma Cell Myeloma	GDSC	RYKIHPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.P86L	KARPAS-620	haematopoietic_and_lymphoid_tissue	COSMIC	RYKIHPD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R70H	SIDM00251	Gastric Carcinoma	GDSC	RYKIHPD	LIG_APCC_ABBAyCdc20_2	0.8244
p.R70H	ACH-000949	Gastric Cancer	CCLE	RYKIHPD	LIG_APCC_ABBAyCdc20_2	0.8244
p.R70H	TGBC11TKB	stomach	COSMIC	RYKIHPD	LIG_APCC_ABBAyCdc20_2	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95992	Cholesterol 25-hydroxylase	LIG_APCC_ABBAyCdc20_2	70:76	RYKIHPD	APC,CDC20,FZR1	0.7352	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons