DegronMD

Uniprot ID: Q9HD26

Source protein: Golgi-associated PDZ and coiled-coil motif-containing protein

Source gene: GOPC

Class: LIG_APCC_ABBAyCdc20_2

Location: 390:396

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5456

ASA_SCORE: 84.8714

COIL: 0.3684

CONS_SCORE: 0.5059

DSS_SCORE: 0.4726

HELIX: 0.133

FCONS_SCORE: 1.0767

RIG_SCORE: 0.8408

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G402D	TCGA-A5-A0G2	UCEC	TCGA	RYRLYLD	LIG_APCC_ABBAyCdc20_2	0.1667
p.V381I	TCGA-A6-2681	COAD	TCGA	RYRLYLD	LIG_APCC_ABBAyCdc20_2	0.0833
p.V381I	SIDM02059	Colorectal Carcinoma	GDSC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	0.0833
p.V381I	SIDM01178	Other Solid Cancers	GDSC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	0.0833
p.V381I	SIDM00168	Head and Neck Carcinoma	GDSC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	0.0833
p.V381I	SW962	vulva	COSMIC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R392S	TCGA-BF-A1Q0	SKCM	TCGA	RYRLYLD	LIG_APCC_ABBAyCdc20_2	0.6316
p.G405C	TCGA-D3-A2JO	SKCM	TCGA	RYRLYLD	LIG_APCC_ABBAyCdc20_2	0.0833
p.G405C	DO47619	SKCM	ICGC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	0.0833
p.D385N	TCGA-XF-A9T0	BLCA	TCGA	RYRLYLD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D402E	DO229035	LICA	ICGC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	0.1667
p.G393S	DO222413	MELA	ICGC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	0.6993
p.G380E	DO232206	RT	ICGC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R384S	DO47374	SKCM	ICGC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	0.1667
p.G394D	DO41235	UCEC	ICGC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	0.7198
p.R390C	SIDM00193	Colorectal Carcinoma	GDSC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	0.8301
p.R390C	SNU-81	large_intestine	COSMIC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	0.8301
p.R392H	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	0.7133
p.R384C	ACH-000887	Brain Cancer	CCLE	RYRLYLD	LIG_APCC_ABBAyCdc20_2	0.1667
p.S404N	ACH-000966	Ovarian Cancer	CCLE	RYRLYLD	LIG_APCC_ABBAyCdc20_2	0.1111
p.S404N	IGROV-1	ovary	COSMIC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	0.1111
p.R382C	ACH-000991	Colon/Colorectal Cancer	CCLE	RYRLYLD	LIG_APCC_ABBAyCdc20_2	0.1111
p.R382C	SNU-81	large_intestine	COSMIC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HD26	Golgi-associated PDZ and coiled-coil motif-containing protein	LIG_APCC_ABBAyCdc20_2	390:396	RYRLYLD	APC,CDC20,FZR1	0.5456	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RYRLYLD

Degron related mutations and impact score

Drug responses associated with GOPC mutations

All proteins holding degron of RYRLYLD