DegronMD - Q9HD26(GOPC)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G402D	TCGA-A5-A0G2	UCEC	TCGA	YRLYLDELE	DEG_APCC_DBOX_1	391:399	Mutation rewiring degron network	0.25
p.G402D	TCGA-A5-A0G2	UCEC	TCGA	RYRLYLD	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.1667
p.V381I	TCGA-A6-2681	COAD	TCGA	YRLYLDELE	DEG_APCC_DBOX_1	391:399	Mutation rewiring degron network	0.0556
p.V381I	TCGA-A6-2681	COAD	TCGA	RYRLYLD	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.0833
p.V381I	SIDM02059	Colorectal Carcinoma	GDSC	YRLYLDELE	DEG_APCC_DBOX_1	391:399	Mutation rewiring degron network	0.0556
p.V381I	SIDM02059	Colorectal Carcinoma	GDSC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.0833
p.V381I	SIDM01178	Other Solid Cancers	GDSC	YRLYLDELE	DEG_APCC_DBOX_1	391:399	Mutation rewiring degron network	0.0556
p.V381I	SIDM01178	Other Solid Cancers	GDSC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.0833
p.V381I	SIDM00168	Head and Neck Carcinoma	GDSC	YRLYLDELE	DEG_APCC_DBOX_1	391:399	Mutation rewiring degron network	0.0556
p.V381I	SIDM00168	Head and Neck Carcinoma	GDSC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.0833
p.V381I	SW962	vulva	COSMIC	YRLYLDELE	DEG_APCC_DBOX_1	391:399	Mutation rewiring degron network	0.0556
p.V381I	SW962	vulva	COSMIC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.0833
p.R392S	TCGA-BF-A1Q0	SKCM	TCGA	YRLYLDELE	DEG_APCC_DBOX_1	391:399	Mutation altering degron motif	0.7427
p.R392S	TCGA-BF-A1Q0	SKCM	TCGA	RYRLYLD	LIG_APCC_ABBAyCdc20_2	390:396	Mutation altering degron motif	0.6316
p.G405C	TCGA-D3-A2JO	SKCM	TCGA	YRLYLDELE	DEG_APCC_DBOX_1	391:399	Mutation rewiring degron network	0.1667
p.G405C	TCGA-D3-A2JO	SKCM	TCGA	RYRLYLD	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.0833
p.G405C	DO47619	SKCM	ICGC	YRLYLDELE	DEG_APCC_DBOX_1	391:399	Mutation rewiring degron network	0.1667
p.G405C	DO47619	SKCM	ICGC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.0833
p.D385N	TCGA-XF-A9T0	BLCA	TCGA	YRLYLDELE	DEG_APCC_DBOX_1	391:399	Mutation rewiring degron network	0.1667
p.D385N	TCGA-XF-A9T0	BLCA	TCGA	RYRLYLD	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.1944
p.D402E	DO229035	LICA	ICGC	YRLYLDELE	DEG_APCC_DBOX_1	391:399	Mutation rewiring degron network	0.25
p.D402E	DO229035	LICA	ICGC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.1667
p.G393S	DO222413	MELA	ICGC	YRLYLDELE	DEG_APCC_DBOX_1	391:399	Mutation altering degron motif	0.6993
p.G393S	DO222413	MELA	ICGC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	390:396	Mutation altering degron motif	0.6993
p.G380E	DO232206	RT	ICGC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.0556
p.R384S	DO47374	SKCM	ICGC	YRLYLDELE	DEG_APCC_DBOX_1	391:399	Mutation rewiring degron network	0.1389
p.R384S	DO47374	SKCM	ICGC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.1667
p.G394D	DO41235	UCEC	ICGC	YRLYLDELE	DEG_APCC_DBOX_1	391:399	Mutation altering degron motif	0.7198
p.G394D	DO41235	UCEC	ICGC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	390:396	Mutation altering degron motif	0.7198
p.R390C	SIDM00193	Colorectal Carcinoma	GDSC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	390:396	Mutation altering degron motif	0.8301
p.R390C	SNU-81	large intestine	COSMIC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	390:396	Mutation altering degron motif	0.8301
p.R392H	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	YRLYLDELE	DEG_APCC_DBOX_1	391:399	Mutation altering degron motif	0.8244
p.R392H	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	390:396	Mutation altering degron motif	0.7133
p.K408N	ACH-000679	Esophageal Cancer	CCLE	YRLYLDELE	DEG_APCC_DBOX_1	391:399	Mutation rewiring degron network	0.0833
p.K408N	OE19	oesophagus	COSMIC	YRLYLDELE	DEG_APCC_DBOX_1	391:399	Mutation rewiring degron network	0.0833
p.R384C	ACH-000887	Brain Cancer	CCLE	YRLYLDELE	DEG_APCC_DBOX_1	391:399	Mutation rewiring degron network	0.1389
p.R384C	ACH-000887	Brain Cancer	CCLE	RYRLYLD	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.1667
p.S404N	ACH-000966	Ovarian Cancer	CCLE	YRLYLDELE	DEG_APCC_DBOX_1	391:399	Mutation rewiring degron network	0.1944
p.S404N	ACH-000966	Ovarian Cancer	CCLE	RYRLYLD	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.1111
p.S404N	IGROV-1	ovary	COSMIC	YRLYLDELE	DEG_APCC_DBOX_1	391:399	Mutation rewiring degron network	0.1944
p.S404N	IGROV-1	ovary	COSMIC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.1111
p.R382C	ACH-000991	Colon/Colorectal Cancer	CCLE	YRLYLDELE	DEG_APCC_DBOX_1	391:399	Mutation rewiring degron network	0.0833
p.R382C	ACH-000991	Colon/Colorectal Cancer	CCLE	RYRLYLD	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.1111
p.R382C	SNU-81	large intestine	COSMIC	YRLYLDELE	DEG_APCC_DBOX_1	391:399	Mutation rewiring degron network	0.0833
p.R382C	SNU-81	large intestine	COSMIC	RYRLYLD	LIG_APCC_ABBAyCdc20_2	390:396	Mutation rewiring degron network	0.1111

Kaplan plot for GOPC in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GOPC

UniProt ID: Q9HD26

Entrez ID: 57120

Protein name: Golgi-associated PDZ and coiled-coil motif-containing protein (CFTR-associated ligand) (Fused in glioblastoma) (PDZ protein interacting specifically with TC10) (PIST)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GOPC in