DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_COP1_1

Location: 1447:1457

E3 ligase: COP1

DEGRON score: 0.8516

ASA_SCORE: 87.9364

COIL: 0.9207

CONS_SCORE: 0.3107

DSS_SCORE: 0.68

HELIX: 0.0334

FCONS_SCORE: 0.9612

RIG_SCORE: 0.6272

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1464K	TCGA-E6-A1LX	UCEC	TCGA	SASTEPAVPTP	DEG_COP1_1	0.1389
p.E1464K	TCGA-EO-A3AV	UCEC	TCGA	SASTEPAVPTP	DEG_COP1_1	0.1389
p.E1464K	TCGA-KK-A59V	PRAD	TCGA	SASTEPAVPTP	DEG_COP1_1	0.1389
p.E1467K	DO6585	CLLE	ICGC	SASTEPAVPTP	DEG_COP1_1	0.0556
p.E1467K	DO51346	PRAD	ICGC	SASTEPAVPTP	DEG_COP1_1	0.0556
p.E1467K	DO41020	UCEC	ICGC	SASTEPAVPTP	DEG_COP1_1	0.0556
p.E1467K	DO52412	UCEC	ICGC	SASTEPAVPTP	DEG_COP1_1	0.0556
p.P1439L	DO32772	PAAD	ICGC	SASTEPAVPTP	DEG_COP1_1	0.1111
p.A1453T	SIDM00855	Other Sarcomas	GDSC	SASTEPAVPTP	DEG_COP1_1	0.6028
p.A1453T	SIDM00760	Small Cell Lung Carcinoma	GDSC	SASTEPAVPTP	DEG_COP1_1	0.6028
p.P1457A	SIDM00582	Pancreatic Carcinoma	GDSC	SASTEPAVPTP	DEG_COP1_1	0.6392
p.P1457A	KP-2	pancreas	COSMIC	SASTEPAVPTP	DEG_COP1_1	0.6392
p.K1465T	SIDM01450	Gastric Carcinoma	GDSC	SASTEPAVPTP	DEG_COP1_1	0.2222
p.K1465T	ACH-000898	Gastric Cancer	CCLE	SASTEPAVPTP	DEG_COP1_1	0.2222
p.A1448D	ACH-000431	Lung Cancer	CCLE	SASTEPAVPTP	DEG_COP1_1	0.6682
p.Q1459H	ACH-001698	Head and Neck Cancer	CCLE	SASTEPAVPTP	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HC84	Mucin-5B	DEG_COP1_1	1447:1457	SASTEPAVPTP	COP1	0.8516	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons