DegronMD

Uniprot ID: Q5H9U9

Source protein: Probable ATP-dependent RNA helicase DDX60-like

Source gene: DDX60L

Class: DEG_COP1_1

Location: 467:475

E3 ligase: COP1

DEGRON score: 0.5236

ASA_SCORE: 75.7889

COIL: 0.8417

CONS_SCORE: 0.2773

DSS_SCORE: 0.2934

HELIX: 0.11

FCONS_SCORE: 0.9568

RIG_SCORE: 0.7812

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V471A	TCGA-DI-A1BU	UCEC	TCGA	SDDPVVPSL	DEG_COP1_1	0.5825
p.V471A	DO42023	UCEC	ICGC	SDDPVVPSL	DEG_COP1_1	0.5825
p.P470S	TCGA-EE-A3J5	SKCM	TCGA	SDDPVVPSL	DEG_COP1_1	0.5641
p.P470S	DO47331	SKCM	ICGC	SDDPVVPSL	DEG_COP1_1	0.5641
p.P473L	TCGA-FR-A8YC	SKCM	TCGA	SDDPVVPSL	DEG_COP1_1	0.7582
p.P473L	DO50301	SKCM	ICGC	SDDPVVPSL	DEG_COP1_1	0.7582
p.P470L	DO222751	BTCA	ICGC	SDDPVVPSL	DEG_COP1_1	0.6471
p.L462S	DO50424	PRAD	ICGC	SDDPVVPSL	DEG_COP1_1	0.1944
p.D469N	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	SDDPVVPSL	DEG_COP1_1	0.5821
p.D469N	SIDM01318	Hepatocellular Carcinoma	GDSC	SDDPVVPSL	DEG_COP1_1	0.5821
p.D469N	SIDM01590	Breast Carcinoma	GDSC	SDDPVVPSL	DEG_COP1_1	0.5821
p.D469Y	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	SDDPVVPSL	DEG_COP1_1	0.6214
p.D469Y	NCI-H1573	lung	COSMIC	SDDPVVPSL	DEG_COP1_1	0.6214

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5H9U9	Probable ATP-dependent RNA helicase DDX60-like	DEG_COP1_1	467:475	SDDPVVPSL	COP1	0.5236	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons