DegronMD

Uniprot ID: A7KAX9

Source protein: Rho GTPase-activating protein 32

Source gene: ARHGAP32

Class: DEG_COP1_1

Location: 47:56

E3 ligase: COP1

DEGRON score: 0.9115

ASA_SCORE: 83.49

COIL: 0.7117

CONS_SCORE: 0.3097

DSS_SCORE: 0.536

HELIX: 0.245

FCONS_SCORE: 1.0573

RIG_SCORE: 0.6859

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R63Q	TCGA-EI-6917	READ	TCGA	SEEDDFVPEL	DEG_COP1_1	0.1389
p.R63Q	DO36881	READ	ICGC	SEEDDFVPEL	DEG_COP1_1	0.1389
p.P62H	TCGA-EL-A3T9	THCA	TCGA	SEEDDFVPEL	DEG_COP1_1	0.1667
p.P62H	DO39635	THCA	ICGC	SEEDDFVPEL	DEG_COP1_1	0.1667
p.R65W	TCGA-SX-A71V	KIRP	TCGA	SEEDDFVPEL	DEG_COP1_1	0.0833
p.R65W	DO49780	KIRP	ICGC	SEEDDFVPEL	DEG_COP1_1	0.0833
p.R63L	DO233936	GACA	ICGC	SEEDDFVPEL	DEG_COP1_1	0.1389
p.G51D	DO50861	LICA	ICGC	SEEDDFVPEL	DEG_COP1_1	0.7198
p.H50R	DO26769	LUSC	ICGC	SEEDDFVPEL	DEG_COP1_1	0.8244
p.G38S	DO219331	PRAD	ICGC	SEEDDFVPEL	DEG_COP1_1	0.0833
p.V39A	DO51269	SKCM	ICGC	SEEDDFVPEL	DEG_COP1_1	0.1111
p.P41Q	DO38171	SKCM	ICGC	SEEDDFVPEL	DEG_COP1_1	0.1667
p.P41L	DO47767	STAD	ICGC	SEEDDFVPEL	DEG_COP1_1	0.1667
p.G57D	DO38328	STAD	ICGC	SEEDDFVPEL	DEG_COP1_1	0.3056
p.P37L	DO41871	UCEC	ICGC	SEEDDFVPEL	DEG_COP1_1	0.1667
p.Q60H	DO42665	UCEC	ICGC	SEEDDFVPEL	DEG_COP1_1	0.2222
p.L56P	SIDM01045	Endometrial Carcinoma	GDSC	SEEDDFVPEL	DEG_COP1_1	0.6471
p.L56P	ACH-000978	Endometrial/Uterine Cancer	CCLE	SEEDDFVPEL	DEG_COP1_1	0.6471
p.L56P	EN	endometrium	COSMIC	SEEDDFVPEL	DEG_COP1_1	0.6471
p.H57R	SIDM01015	Chronic Myelogenous Leukemia	GDSC	SEEDDFVPEL	DEG_COP1_1	0.3056
p.E49K	SIDM01102	Non-Cancerous	GDSC	SEEDDFVPEL	DEG_COP1_1	0.591
p.E49K	ACH-002316	Non-Cancerous	CCLE	SEEDDFVPEL	DEG_COP1_1	0.591
p.E49K	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	SEEDDFVPEL	DEG_COP1_1	0.591
p.Y57C	ACH-000786	Lymphoma	CCLE	SEEDDFVPEL	DEG_COP1_1	0.3056
p.Y57C	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	SEEDDFVPEL	DEG_COP1_1	0.3056
p.A63T	ACH-000999	Colon/Colorectal Cancer	CCLE	SEEDDFVPEL	DEG_COP1_1	0.1389
p.A63T	SNU-1040	large_intestine	COSMIC	SEEDDFVPEL	DEG_COP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7KAX9	Rho GTPase-activating protein 32	DEG_COP1_1	47:56	SEEDDFVPEL	COP1	0.9115	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SEEDDFVPEL

Degron related mutations and impact score

Drug responses associated with ARHGAP32 mutations

All proteins holding degron of SEEDDFVPEL