DegronMD

Uniprot ID: Q9UHI8

Source protein: A disintegrin and metalloproteinase with thrombospondin motifs 1

Source gene: ADAMTS1

Class: DEG_COP1_1

Location: 54:65

E3 ligase: COP1

DEGRON score: 0.9045

ASA_SCORE: 89.0917

COIL: 0.5734

CONS_SCORE: 0.4648

DSS_SCORE: 0.5488

HELIX: 0.0855

FCONS_SCORE: 1.4357

RIG_SCORE: 0.745

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R75H	TCGA-UZ-A9PL	KIRP	TCGA	SEEDEELVVPEL	DEG_COP1_1	0.0556
p.R75H	DO219701	KIRP	ICGC	SEEDEELVVPEL	DEG_COP1_1	0.0556
p.T73S	DO19733	KIRC	ICGC	SEEDEELVVPEL	DEG_COP1_1	0.1111
p.E55K	DO228424	MALY	ICGC	SEEDEELVVPEL	DEG_COP1_1	0.7022
p.R52H	DO38404	STAD	ICGC	SEEDEELVVPEL	DEG_COP1_1	0.2778
p.P69R	DO229272	THCA	ICGC	SEEDEELVVPEL	DEG_COP1_1	0.2222
p.A68T	DO229208	THCA	ICGC	SEEDEELVVPEL	DEG_COP1_1	0.25
p.A68V	SIDM01003	T-Lymphoblastic Leukemia	GDSC	SEEDEELVVPEL	DEG_COP1_1	0.25
p.R75G	ACH-000463	Lung Cancer	CCLE	SEEDEELVVPEL	DEG_COP1_1	0.0556
p.E64Q	ACH-000831	Endometrial/Uterine Cancer	CCLE	SEEDEELVVPEL	DEG_COP1_1	0.6744

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHI8	A disintegrin and metalloproteinase with thrombospondin motifs 1	DEG_COP1_1	54:65	SEEDEELVVPEL	COP1	0.9045	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons